Taxel_therapies more effective in the TEfus+ biomarker signature
By subgroup:
| subtype | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| —+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| –++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| -+++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +— | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +–+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-+- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +-++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++– | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++-+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 | |
| +++- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | af = 1, hr = 1 | |
| ++++ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 |
By signature:
| signature | var | Other | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53- & AR- | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TP53+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1, hr = 1 | af = 1, hr = 1 | |
| DRD+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.075, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 13.1, median = 9.4 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 1.49, hr = 0.66 | af = 1, hr = 1 | af = 1, hr = 1 | |
| TEfus+ | param | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.037, shape = 1.05 | scale = 0.112, shape = 1.05 | scale = 0.112, shape = 1.05 |
| summary | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | mean = 26.6, median = 19.1 | mean = 8.8, median = 6.3 | mean = 8.8, median = 6.3 | |
| effect | af = 1, hr = 1 | af = 1, hr = 1 | af = 3.03, hr = 0.31 | af = 1, hr = 1 | af = 1, hr = 1 |
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The overall error was 0.22.
The corresponding errors separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.072 0.112 0.028 0.026
The overall power was 0.616.
The corresponding power separate for the different treatments were:
Hormone_therapies Taxel_therapies Carboplatin Niraparib
0.000 0.616 0.000 0.000
| signature | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 5 | 21 | 1 | 1 |
| futility | 0 | 18 | 0 | 0 | 4 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 432 (394, 467) | 170 (108, 250) | 187 (104, 269) | 180 (119, 253) | 173 (113, 239) | |
| n_unique | 399 (364, 430) | 157 (99, 231) | 171 (94, 251) | 168 (108, 237) | 160 (102, 221) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | |
| time_stop | NA (NA, NA) | 7 (3, 29) | 6 (5, 15) | 11 (11, 11) | 18 (9, 35) | |
| post_p | NA (NA, NA) | 0.06 (0, 0.37) | 1 (0.91, 1) | 0.07 (0, 0.39) | 0.05 (0, 0.38) | |
| rate | 0.096 (0.089, 0.103) | 0.113 (0.102, 0.128) | 0.067 (0.057, 0.083) | 0.112 (0.101, 0.126) | 0.113 (0.101, 0.128) | |
| TP53- & AR- | graduation | 0 | 29 | 115 | 9 | 9 |
| futility | 0 | 259 | 11 | 205 | 236 | |
| max_n | 0 | 18 | 11 | 19 | 11 | |
| n | 177 (153, 201) | 61 (26, 130) | 60 (26, 119) | 69 (27, 132) | 64 (27, 117) | |
| n_unique | 165 (141, 188) | 57 (25, 123) | 54 (24, 112) | 64 (24, 123) | 58 (24, 110) | |
| time_trial | 36 (36, 36) | 28 (9, 36) | 36 (14, 36) | 36 (16, 36) | 36 (15, 36) | |
| time_stop | NA (NA, NA) | 15 (7, 30) | 16 (10, 28) | 22 (13, 33) | 22 (13, 33) | |
| post_p | NA (NA, NA) | 0.25 (0.04, 0.73) | 0.94 (0.48, 1) | 0.26 (0.03, 0.72) | 0.22 (0.03, 0.69) | |
| rate | 0.101 (0.091, 0.114) | 0.115 (0.096, 0.142) | 0.078 (0.058, 0.103) | 0.113 (0.096, 0.144) | 0.117 (0.098, 0.147) | |
| TP53+ | graduation | 0 | 1 | 31 | 3 | 2 |
| futility | 0 | 70 | 3 | 61 | 75 | |
| max_n | 0 | 7 | 26 | 8 | 8 | |
| n | 194 (172, 216) | 79 (36, 116) | 90 (41, 137) | 81 (45, 118) | 79 (40, 116) | |
| n_unique | 178 (156, 199) | 72 (34, 108) | 83 (38, 128) | 74 (41, 108) | 73 (36, 108) | |
| time_trial | 36 (36, 36) | 36 (28, 36) | 36 (36, 36) | 36 (31, 36) | 36 (24, 36) | |
| time_stop | NA (NA, NA) | 22 (10, 33) | 10 (7, 20) | 22 (13, 33) | 21 (12, 32) | |
| post_p | NA (NA, NA) | 0.1 (0.01, 0.47) | 1 (0.84, 1) | 0.11 (0.01, 0.46) | 0.1 (0.01, 0.48) | |
| rate | 0.093 (0.083, 0.104) | 0.114 (0.098, 0.138) | 0.062 (0.049, 0.079) | 0.114 (0.097, 0.136) | 0.115 (0.097, 0.138) | |
| DRD+ | graduation | 0 | 2 | 20 | 1 | 0 |
| futility | 0 | 45 | 0 | 48 | 74 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 117 (100, 133) | 42 (25, 66) | 42 (20, 74) | 59 (38, 84) | 55 (35, 82) | |
| n_unique | 107 (90, 122) | 38 (22, 61) | 38 (18, 68) | 54 (35, 79) | 51 (31, 76) | |
| time_trial | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (36, 36) | 36 (28, 36) | |
| time_stop | NA (NA, NA) | 28 (19, 34) | 22 (18, 27) | 25 (14, 35) | 24 (16, 34) | |
| post_p | NA (NA, NA) | 0.18 (0.02, 0.62) | 0.94 (0.54, 1) | 0.13 (0.02, 0.56) | 0.12 (0.01, 0.49) | |
| rate | 0.091 (0.078, 0.105) | 0.113 (0.089, 0.147) | 0.064 (0.048, 0.093) | 0.113 (0.095, 0.138) | 0.117 (0.095, 0.144) | |
| TEfus+ | graduation | 0 | 0 | 308 | 0 | 1 |
| futility | 0 | 207 | 0 | 228 | 215 | |
| max_n | 0 | 2 | 21 | 2 | 2 | |
| n | 163 (143, 183) | 51 (27, 94) | 72 (26, 141) | 59 (32, 97) | 54 (29, 101) | |
| n_unique | 150 (130, 169) | 46 (24, 87) | 65 (25, 128) | 54 (29, 88) | 49 (27, 92) | |
| time_trial | 36 (36, 36) | 36 (19, 36) | 24 (10, 36) | 36 (20, 36) | 36 (19, 36) | |
| time_stop | NA (NA, NA) | 25 (16, 34) | 15 (9, 29) | 26 (17, 34) | 24 (16, 34) | |
| post_p | NA (NA, NA) | 0.02 (0, 0.18) | 1 (1, 1) | 0.01 (0, 0.15) | 0.02 (0, 0.15) | |
| rate | 0.074 (0.065, 0.086) | 0.115 (0.095, 0.145) | 0.036 (0.029, 0.044) | 0.114 (0.095, 0.14) | 0.115 (0.095, 0.143) |
| subtype | var | Control | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 299 | 144 | 215 | 247 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 18 | 11 | 19 | 11 | |
| n | 113 (93, 134) | 39 (17, 99) | 31 (10, 82) | 38 (9, 90) | 32 (10, 84) | |
| n_unique | 105 (85, 126) | 37 (17, 94) | 29 (9, 77) | 36 (8, 86) | 30 (9, 78) | |
| post_p | NA (NA, NA) | 0.47 (0.11, 0.89) | 0.43 (0.09, 0.88) | 0.47 (0.09, 0.89) | 0.42 (0.09, 0.89) | |
| rate | 0.112 (0.099, 0.129) | 0.116 (0.094, 0.153) | 0.116 (0.091, 0.18) | 0.116 (0.093, 0.184) | 0.119 (0.093, 0.18) | |
| —+ | graduation | 0 | 368 | 364 | 333 | 350 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 19 | 31 | 20 | 12 | |
| n | 21 (14, 28) | 6 (2, 16) | 8 (3, 22) | 6 (2, 17) | 5 (2, 17) | |
| n_unique | 19 (12, 26) | 5 (2, 14) | 7 (2, 21) | 5 (1, 16) | 5 (1, 15) | |
| post_p | NA (NA, NA) | 0.27 (0.09, 0.55) | 0.92 (0.58, 1) | 0.26 (0.11, 0.55) | 0.28 (0.1, 0.57) | |
| rate | 0.074 (0.05, 0.111) | 0.127 (0.076, 0.297) | 0.036 (0.02, 0.07) | 0.127 (0.078, 0.356) | 0.134 (0.08, 0.381) | |
| –+- | graduation | 0 | 85 | 54 | 65 | 78 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 26 | 8 | 8 | |
| n | 63 (50, 77) | 25 (8, 59) | 22 (7, 53) | 24 (6, 52) | 24 (7, 53) | |
| n_unique | 58 (44, 72) | 24 (8, 55) | 21 (6, 49) | 22 (6, 50) | 23 (6, 49) | |
| post_p | NA (NA, NA) | 0.44 (0.09, 0.89) | 0.48 (0.13, 0.88) | 0.44 (0.11, 0.87) | 0.46 (0.12, 0.86) | |
| rate | 0.114 (0.094, 0.14) | 0.117 (0.093, 0.196) | 0.118 (0.087, 0.193) | 0.122 (0.091, 0.235) | 0.121 (0.089, 0.212) | |
| –++ | graduation | 0 | 247 | 330 | 261 | 251 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 9 | 43 | 9 | 8 | |
| n | 47 (36, 57) | 10 (4, 31) | 22 (9, 50) | 11 (3, 32) | 10 (3, 29) | |
| n_unique | 43 (33, 54) | 9 (3, 30) | 21 (8, 46) | 10 (3, 30) | 9 (3, 27) | |
| post_p | NA (NA, NA) | 0.18 (0.04, 0.44) | 0.99 (0.84, 1) | 0.21 (0.05, 0.5) | 0.19 (0.06, 0.49) | |
| rate | 0.075 (0.058, 0.096) | 0.123 (0.084, 0.241) | 0.036 (0.025, 0.052) | 0.118 (0.078, 0.25) | 0.123 (0.079, 0.258) | |
| -+– | graduation | 0 | 320 | 158 | 235 | 269 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 18 | 11 | 19 | 11 | |
| n | 21 (14, 28) | 5 (1, 16) | 6 (1, 18) | 10 (3, 22) | 9 (3, 22) | |
| n_unique | 19 (13, 26) | 4 (1, 15) | 5 (1, 16) | 9 (3, 21) | 8 (2, 20) | |
| post_p | NA (NA, NA) | 0.48 (0.21, 0.83) | 0.48 (0.16, 0.84) | 0.45 (0.17, 0.84) | 0.43 (0.17, 0.85) | |
| rate | 0.113 (0.084, 0.16) | 0.125 (0.071, 0.36) | 0.122 (0.07, 0.332) | 0.125 (0.081, 0.289) | 0.128 (0.079, 0.307) | |
| -+-+ | graduation | 0 | 381 | 366 | 339 | 359 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 19 | 31 | 20 | 12 | |
| n | 21 (14, 29) | 5 (1, 16) | 5 (1, 20) | 8 (3, 19) | 7 (2, 19) | |
| n_unique | 19 (12, 26) | 4 (1, 15) | 5 (1, 19) | 8 (3, 18) | 7 (2, 17) | |
| post_p | NA (NA, NA) | 0.3 (0.11, 0.6) | 0.88 (0.51, 0.99) | 0.26 (0.09, 0.59) | 0.25 (0.1, 0.53) | |
| rate | 0.076 (0.053, 0.111) | 0.131 (0.073, 0.431) | 0.036 (0.013, 0.082) | 0.119 (0.076, 0.255) | 0.125 (0.082, 0.336) | |
| -++- | graduation | 0 | 121 | 71 | 98 | 123 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 26 | 8 | 7 | |
| n | 12 (7, 17) | 4 (1, 10) | 4 (1, 10) | 6 (2, 13) | 5 (2, 12) | |
| n_unique | 11 (6, 16) | 4 (1, 9) | 3 (1, 9) | 5 (2, 12) | 5 (2, 12) | |
| post_p | NA (NA, NA) | 0.46 (0.23, 0.83) | 0.45 (0.23, 0.79) | 0.46 (0.21, 0.82) | 0.44 (0.21, 0.8) | |
| rate | 0.114 (0.073, 0.17) | 0.125 (0.064, 0.386) | 0.132 (0.068, 0.396) | 0.125 (0.071, 0.343) | 0.135 (0.073, 0.358) | |
| -+++ | graduation | 0 | 263 | 332 | 272 | 264 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 9 | 43 | 9 | 8 | |
| n | 13 (8, 18) | 4 (1, 11) | 3 (0, 11) | 5 (2, 12) | 5 (2, 13) | |
| n_unique | 11 (7, 16) | 4 (1, 10) | 3 (0, 10) | 5 (2, 11) | 4 (2, 12) | |
| post_p | NA (NA, NA) | 0.35 (0.17, 0.61) | 0.78 (0.41, 0.96) | 0.32 (0.14, 0.62) | 0.31 (0.13, 0.63) | |
| rate | 0.074 (0.045, 0.123) | 0.128 (0.07, 0.396) | 0.042 (0, 0.126) | 0.132 (0.071, 0.326) | 0.131 (0.071, 0.345) | |
| +— | graduation | 0 | 23 | 21 | 1 | 5 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 20 (14, 27) | 9 (2, 18) | 10 (3, 20) | 8 (3, 17) | 8 (2, 17) | |
| n_unique | 18 (12, 25) | 8 (2, 16) | 10 (3, 19) | 7 (2, 16) | 7 (2, 15) | |
| post_p | NA (NA, NA) | 0.43 (0.18, 0.84) | 0.46 (0.16, 0.84) | 0.47 (0.19, 0.86) | 0.48 (0.19, 0.82) | |
| rate | 0.115 (0.082, 0.157) | 0.128 (0.078, 0.342) | 0.124 (0.081, 0.27) | 0.121 (0.074, 0.308) | 0.12 (0.073, 0.323) | |
| +–+ | graduation | 0 | 221 | 324 | 229 | 218 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 21 | 2 | 2 | |
| n | 17 (12, 24) | 5 (2, 14) | 8 (3, 18) | 5 (2, 13) | 5 (2, 13) | |
| n_unique | 16 (11, 22) | 4 (2, 13) | 7 (2, 17) | 4 (1, 12) | 4 (1, 12) | |
| post_p | NA (NA, NA) | 0.29 (0.14, 0.55) | 0.88 (0.58, 0.99) | 0.3 (0.12, 0.58) | 0.31 (0.14, 0.62) | |
| rate | 0.075 (0.046, 0.11) | 0.128 (0.078, 0.374) | 0.038 (0.02, 0.072) | 0.131 (0.071, 0.359) | 0.128 (0.069, 0.365) | |
| +-+- | graduation | 0 | 85 | 54 | 65 | 78 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 26 | 8 | 8 | |
| n | 16 (11, 22) | 6 (2, 15) | 8 (3, 17) | 6 (2, 15) | 6 (2, 15) | |
| n_unique | 15 (10, 20) | 6 (1, 14) | 7 (2, 15) | 6 (2, 14) | 6 (2, 14) | |
| post_p | NA (NA, NA) | 0.45 (0.19, 0.83) | 0.48 (0.17, 0.84) | 0.45 (0.19, 0.81) | 0.45 (0.2, 0.82) | |
| rate | 0.114 (0.078, 0.164) | 0.128 (0.073, 0.391) | 0.124 (0.075, 0.294) | 0.13 (0.077, 0.553) | 0.129 (0.073, 0.432) | |
| +-++ | graduation | 0 | 247 | 330 | 261 | 251 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 9 | 43 | 9 | 8 | |
| n | 17 (12, 24) | 5 (2, 14) | 7 (2, 19) | 5 (2, 13) | 5 (2, 13) | |
| n_unique | 16 (10, 22) | 5 (1, 12) | 7 (2, 17) | 5 (1, 12) | 4 (1, 12) | |
| post_p | NA (NA, NA) | 0.27 (0.13, 0.58) | 0.89 (0.56, 0.99) | 0.3 (0.12, 0.55) | 0.3 (0.12, 0.59) | |
| rate | 0.076 (0.049, 0.113) | 0.133 (0.075, 0.358) | 0.037 (0.016, 0.074) | 0.133 (0.074, 0.382) | 0.133 (0.065, 0.375) | |
| ++– | graduation | 0 | 67 | 41 | 50 | 77 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 0 | 0 | 0 | 0 | |
| n | 11 (7, 17) | 5 (1, 11) | 4 (1, 10) | 6 (2, 13) | 5 (2, 12) | |
| n_unique | 11 (6, 16) | 4 (1, 10) | 4 (1, 9) | 6 (2, 12) | 5 (2, 11) | |
| post_p | NA (NA, NA) | 0.48 (0.23, 0.82) | 0.44 (0.22, 0.8) | 0.46 (0.2, 0.84) | 0.43 (0.21, 0.82) | |
| rate | 0.114 (0.071, 0.175) | 0.125 (0.058, 0.41) | 0.13 (0.066, 0.53) | 0.128 (0.071, 0.36) | 0.133 (0.074, 0.374) | |
| ++-+ | graduation | 0 | 238 | 327 | 243 | 246 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 2 | 21 | 2 | 2 | |
| n | 12 (8, 18) | 4 (1, 11) | 3 (0, 11) | 5 (2, 12) | 5 (2, 12) | |
| n_unique | 11 (7, 16) | 3 (1, 9) | 3 (0, 10) | 5 (1, 11) | 4 (2, 11) | |
| post_p | NA (NA, NA) | 0.34 (0.16, 0.64) | 0.79 (0.44, 0.96) | 0.32 (0.14, 0.63) | 0.31 (0.13, 0.61) | |
| rate | 0.074 (0.043, 0.125) | 0.132 (0.067, 0.539) | 0.04 (0.007, 0.105) | 0.129 (0.072, 0.375) | 0.136 (0.074, 0.359) | |
| +++- | graduation | 0 | 121 | 71 | 98 | 123 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 7 | 26 | 8 | 7 | |
| n | 12 (7, 17) | 4 (1, 11) | 4 (1, 10) | 6 (2, 13) | 5 (2, 12) | |
| n_unique | 11 (6, 16) | 4 (1, 10) | 4 (1, 9) | 5 (2, 12) | 5 (2, 12) | |
| post_p | NA (NA, NA) | 0.44 (0.22, 0.8) | 0.45 (0.2, 0.79) | 0.48 (0.22, 0.83) | 0.43 (0.2, 0.8) | |
| rate | 0.114 (0.07, 0.184) | 0.135 (0.069, 0.454) | 0.133 (0.067, 0.418) | 0.122 (0.075, 0.355) | 0.133 (0.075, 0.462) | |
| ++++ | graduation | 0 | 263 | 332 | 272 | 264 |
| futility | 0 | 0 | 0 | 0 | 0 | |
| max_n | 0 | 9 | 43 | 9 | 8 | |
| n | 12 (8, 18) | 4 (1, 11) | 3 (0, 11) | 5 (2, 12) | 5 (2, 12) | |
| n_unique | 11 (7, 17) | 4 (1, 10) | 3 (0, 10) | 5 (2, 11) | 4 (2, 11) | |
| post_p | NA (NA, NA) | 0.35 (0.17, 0.68) | 0.81 (0.47, 0.96) | 0.32 (0.14, 0.63) | 0.33 (0.15, 0.7) | |
| rate | 0.079 (0.047, 0.131) | 0.13 (0.063, 0.393) | 0.036 (0, 0.111) | 0.13 (0.071, 0.36) | 0.126 (0.069, 0.317) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 5 | 21 | 1 | 1 |
| time_stop | 6 (4, 8) | 6 (5, 15) | 11 (11, 11) | 7 (7, 7) | |
| n_trt | 31 (28, 50) | 38 (29, 75) | 58 (58, 58) | 34 (34, 34) | |
| n_control | 64 (50, 95) | 71 (54, 158) | 114 (114, 114) | 64 (64, 64) | |
| post_p | 0.92 (0.9, 0.98) | 0.98 (0.92, 1) | 0.98 (0.98, 0.98) | 0.94 (0.94, 0.94) | |
| order | 1 (1, 2.6) | 1 (1, 2) | 1 (1, 1) | 1 (1, 1) | |
| TP53- & AR- | count | 29 | 115 | 9 | 9 |
| time_stop | 10 (6, 14) | 16 (10, 30) | 13 (9, 19) | 12 (9, 13) | |
| n_trt | 30 (25, 50) | 34 (25, 68) | 28 (25, 53) | 28 (27, 36) | |
| n_control | 36 (25, 60) | 68 (40, 136) | 55 (47, 85) | 49 (40, 61) | |
| post_p | 0.9 (0.86, 0.98) | 0.96 (0.88, 1) | 0.9 (0.89, 0.95) | 0.93 (0.87, 0.97) | |
| order | 1 (1, 1) | 1 (1, 2) | 1 (1, 2.2) | 1 (1, 2) | |
| TP53+ | count | 1 | 31 | 3 | 2 |
| time_stop | 8 (8, 8) | 10 (8, 21) | 12 (11, 21) | 10 (8, 12) | |
| n_trt | 26 (26, 26) | 34 (26, 64) | 31 (26, 37) | 32 (30, 33) | |
| n_control | 33 (33, 33) | 52 (31, 122) | 62 (48, 108) | 46 (36, 56) | |
| post_p | 0.88 (0.88, 0.88) | 0.99 (0.94, 1) | 0.93 (0.89, 0.97) | 0.97 (0.95, 0.99) | |
| order | 1 (1, 1) | 1 (1, 2) | 2 (1.2, 2) | 1.5 (1.1, 1.9) | |
| DRD+ | count | 2 | 20 | 1 | |
| time_stop | 18 (14, 21) | 22 (18, 27) | 10 (10, 10) | ||
| n_trt | 28 (26, 30) | 30 (26, 42) | 30 (30, 30) | ||
| n_control | 46 (36, 55) | 61 (46, 87) | 27 (27, 27) | ||
| post_p | 0.92 (0.91, 0.93) | 0.98 (0.93, 1) | 0.98 (0.98, 0.98) | ||
| order | 2.5 (2.1, 2.9) | 2 (1, 3) | 1 (1, 1) | ||
| TEfus+ | count | 308 | 1 | ||
| time_stop | 15 (9, 29) | 12 (12, 12) | |||
| n_trt | 43 (26, 105) | 25 (25, 25) | |||
| n_control | 59 (33, 123) | 49 (49, 49) | |||
| post_p | 1 (0.95, 1) | 0.96 (0.96, 0.96) | |||
| order | 1 (1, 2) | 1 (1, 1) |
| signature | var | Hormone_therapies | Taxel_therapies | Carboplatin | Niraparib |
|---|---|---|---|---|---|
| all | count | 18 | 4 | ||
| time_stop | 10 (3, 29) | 26 (14, 35) | |||
| n_trt | 56 (27, 106) | 94 (64, 133) | |||
| n_control | 104 (35, 384) | 286 (153, 422) | |||
| post_p | 0.02 (0, 0.23) | 0 (0, 0.01) | |||
| order | 2 (1, 6) | 4.5 (1.3, 7) | |||
| TP53- & AR- | count | 259 | 11 | 205 | 236 |
| time_stop | 17 (8, 31) | 17 (13, 22) | 22 (14, 33) | 22 (14, 33) | |
| n_trt | 39 (25, 86) | 29 (27, 43) | 35 (25, 98) | 39 (25, 90) | |
| n_control | 74 (33, 145) | 68 (61, 107) | 102 (61, 166) | 104 (56, 162) | |
| post_p | 0.14 (0.04, 0.26) | 0.19 (0.09, 0.23) | 0.13 (0.03, 0.26) | 0.12 (0.03, 0.24) | |
| order | 1 (1, 4) | 1 (1, 2) | 2 (1, 4) | 2 (1, 4) | |
| TP53+ | count | 70 | 3 | 61 | 75 |
| time_stop | 22 (10, 33) | 10 (7, 16) | 22 (14, 33) | 22 (12, 32) | |
| n_trt | 42 (26, 68) | 28 (26, 46) | 44 (27, 83) | 38 (26, 61) | |
| n_control | 109 (47, 171) | 60 (31, 86) | 112 (66, 184) | 104 (56, 175) | |
| post_p | 0.03 (0, 0.22) | 0.19 (0.06, 0.22) | 0.02 (0, 0.08) | 0.02 (0, 0.12) | |
| order | 2 (1, 5) | 1 (1, 1) | 2 (1, 5) | 2 (1, 5) | |
| DRD+ | count | 45 | 48 | 74 | |
| time_stop | 30 (19, 34) | 26 (14, 35) | 24 (16, 34) | ||
| n_trt | 31 (25, 45) | 38 (26, 59) | 36 (26, 52) | ||
| n_control | 86 (52, 110) | 84 (42, 113) | 74 (44, 106) | ||
| post_p | 0.04 (0, 0.17) | 0.03 (0, 0.11) | 0.02 (0, 0.1) | ||
| order | 3 (1.4, 6) | 3 (1, 6) | 3.5 (1, 6) | ||
| TEfus+ | count | 207 | 228 | 215 | |
| time_stop | 25 (16, 34) | 26 (17, 34) | 24 (16, 34) | ||
| n_trt | 38 (26, 67) | 48 (27, 76) | 43 (26, 76) | ||
| n_control | 107 (62, 152) | 112 (62, 159) | 105 (62, 155) | ||
| post_p | 0.01 (0, 0.08) | 0.01 (0, 0.06) | 0.01 (0, 0.07) | ||
| order | 3 (1, 5) | 3 (1, 5) | 3 (1, 5) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 |
| time | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | 6 (4, 8) | ||
| n | 17 (10, 23) | 2 (0, 3) | 7 (4, 9) | 3 (1, 5) | 0 (0, 0) | 0 (0, 1) | 0 (0, 1) | 0 (0, 2) | 2 (0, 4) | 1 (0, 4) | 1 (0, 2) | 1 (0, 3) | 0 (0, 1) | 0 (0, 3) | 0 (0, 1) | 0 (0, 0) | ||
| post_p | 0.69 (0.59, 0.87) | 0.62 (0.61, 0.68) | 0.72 (0.63, 0.87) | 0.56 (0.52, 0.7) | NA (NA, NA) | 0.61 (0.61, 0.61) | NA (NA, NA) | NA (NA, NA) | 0.58 (0.52, 0.63) | 0.65 (0.64, 0.67) | 0.57 (0.53, 0.6) | 0.56 (0.55, 0.62) | 0.63 (0.61, 0.64) | 0.55 (0.55, 0.55) | 0.58 (0.58, 0.58) | NA (NA, NA) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.059 (0.028, 0.091) | 0 (0, 0) | 0 (0, 0.083) | 0 (0, 0.095) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0.128 (0.128, 0.128) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.092) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | ||
| Taxel_therapies | count | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | 21 | |
| time | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | 6 (5, 15) | ||
| n | 9 (5, 16) | 3 (1, 8) | 6 (2, 12) | 9 (5, 13) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 0 (0, 2) | 3 (0, 8) | 3 (1, 5) | 3 (0, 6) | 2 (0, 3) | 0 (0, 3) | 0 (0, 1) | 0 (0, 2) | 0 (0, 2) | ||
| post_p | 0.65 (0.54, 0.86) | 0.64 (0.52, 0.87) | 0.62 (0.54, 0.74) | 0.78 (0.61, 0.96) | 0.54 (0.5, 0.62) | 0.59 (0.52, 0.76) | 0.56 (0.51, 0.63) | 0.62 (0.55, 0.72) | 0.59 (0.51, 0.75) | 0.66 (0.51, 0.84) | 0.6 (0.5, 0.76) | 0.57 (0.53, 0.74) | 0.58 (0.51, 0.62) | 0.69 (0.55, 0.73) | 0.54 (0.52, 0.55) | 0.56 (0.52, 0.78) | ||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.08 (0, 0.121) | 0 (0, 0.126) | 0.082 (0, 0.142) | 0 (0, 0.037) | 0 (0, 0.01) | 0 (0, 0.01) | 0 (0, 0.099) | 0 (0, 0.071) | 0.05 (0, 0.112) | 0 (0, 0.012) | 0.048 (0, 0.122) | 0 (0, 0.056) | 0 (0, 0.118) | 0 (0, 0.051) | 0 (0, 0.148) | 0 (0, 0.015) | ||
| Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | 11 (11, 11) | ||
| n | 19 (19, 19) | 3 (3, 3) | 15 (15, 15) | 3 (3, 3) | 4 (4, 4) | 4 (4, 4) | 0 (0, 0) | 1 (1, 1) | 2 (2, 2) | 0 (0, 0) | 2 (2, 2) | 2 (2, 2) | 0 (0, 0) | 2 (2, 2) | 1 (1, 1) | 0 (0, 0) | ||
| post_p | 0.78 (0.78, 0.78) | 0.68 (0.68, 0.68) | 0.65 (0.65, 0.65) | 0.69 (0.69, 0.69) | 0.5 (0.5, 0.5) | 0.5 (0.5, 0.5) | NA (NA, NA) | 0.64 (0.64, 0.64) | 0.51 (0.51, 0.51) | NA (NA, NA) | 0.59 (0.59, 0.59) | 0.55 (0.55, 0.55) | NA (NA, NA) | 0.71 (0.71, 0.71) | 0.56 (0.56, 0.56) | NA (NA, NA) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.079 (0.079, 0.079) | 0 (0, 0) | 0.079 (0.079, 0.079) | 0 (0, 0) | 0.067 (0.067, 0.067) | 0.053 (0.053, 0.053) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | ||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |
| time | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | 7 (7, 7) | ||
| n | 7 (7, 7) | 0 (0, 0) | 4 (4, 4) | 1 (1, 1) | 3 (3, 3) | 3 (3, 3) | 0 (0, 0) | 4 (4, 4) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 5 (5, 5) | 3 (3, 3) | 0 (0, 0) | 1 (1, 1) | 2 (2, 2) | ||
| post_p | 0.62 (0.62, 0.62) | NA (NA, NA) | 0.71 (0.71, 0.71) | 0.51 (0.51, 0.51) | 0.56 (0.56, 0.56) | 0.52 (0.52, 0.52) | NA (NA, NA) | 0.89 (0.89, 0.89) | NA (NA, NA) | NA (NA, NA) | 0.53 (0.53, 0.53) | 0.71 (0.71, 0.71) | 0.6 (0.6, 0.6) | NA (NA, NA) | 0.52 (0.52, 0.52) | NA (NA, NA) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.058 (0.058, 0.058) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0.112 (0.112, 0.112) | 0.081 (0.081, 0.081) | NA (NA, NA) | 0.05 (0.05, 0.05) | NA (NA, NA) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0.105 (0.105, 0.105) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | ||
| TP53- & AR- | Hormone_therapies | count | 29 | 29 | 29 | 29 | ||||||||||||
| time | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | 10 (6, 14) | ||||||||||||||
| n | 25 (20, 38) | 4 (1, 5) | 1 (0, 4) | 1 (0, 3) | ||||||||||||||
| post_p | 0.86 (0.74, 0.94) | 0.62 (0.52, 0.76) | 0.59 (0.52, 0.84) | 0.56 (0.51, 0.74) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.073 (0.056, 0.101) | 0.017 (0, 0.087) | 0 (0, 0.069) | 0 (0, 0.097) | ||||||||||||||
| Taxel_therapies | count | 115 | 115 | 115 | 115 | |||||||||||||
| time | 16 (10, 30) | 16 (10, 30) | 16 (10, 30) | 16 (10, 30) | ||||||||||||||
| n | 21 (15, 47) | 6 (3, 12) | 3 (0, 7) | 3 (1, 10) | ||||||||||||||
| post_p | 0.8 (0.72, 0.91) | 0.8 (0.61, 0.95) | 0.59 (0.51, 0.81) | 0.7 (0.54, 0.95) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.08 (0.055, 0.103) | 0.028 (0, 0.06) | 0.077 (0, 0.14) | 0.014 (0, 0.071) | ||||||||||||||
| Carboplatin | count | 9 | 9 | 9 | 9 | |||||||||||||
| time | 13 (9, 19) | 13 (9, 19) | 13 (9, 19) | 13 (9, 19) | ||||||||||||||
| n | 19 (15, 35) | 2 (0, 4) | 6 (2, 9) | 4 (1, 12) | ||||||||||||||
| post_p | 0.79 (0.75, 0.85) | 0.6 (0.53, 0.66) | 0.74 (0.53, 0.8) | 0.72 (0.52, 0.83) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.074 (0.063, 0.103) | 0.038 (0, 0.115) | 0.063 (0.026, 0.175) | 0.038 (0, 0.101) | ||||||||||||||
| Niraparib | count | 9 | 9 | 9 | 9 | |||||||||||||
| time | 12 (9, 13) | 12 (9, 13) | 12 (9, 13) | 12 (9, 13) | ||||||||||||||
| n | 17 (12, 23) | 3 (0, 3) | 5 (3, 6) | 7 (2, 8) | ||||||||||||||
| post_p | 0.76 (0.71, 0.91) | 0.58 (0.53, 0.67) | 0.72 (0.54, 0.83) | 0.72 (0.64, 0.86) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.065 (0.024, 0.1) | 0 (0, 0.066) | 0.067 (0, 0.076) | 0.051 (0, 0.08) | ||||||||||||||
| TP53+ | Hormone_therapies | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| time | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | ||||||||||
| n | 23 (23, 23) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 1 (1, 1) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| post_p | 0.89 (0.89, 0.89) | 0.62 (0.62, 0.62) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.052 (0.052, 0.052) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.402 (0.402, 0.402) | NA (NA, NA) | NA (NA, NA) | ||||||||||
| Taxel_therapies | count | 31 | 31 | 31 | 31 | 31 | 31 | 31 | 31 | |||||||||
| time | 10 (8, 21) | 10 (8, 21) | 10 (8, 21) | 10 (8, 21) | 10 (8, 21) | 10 (8, 21) | 10 (8, 21) | 10 (8, 21) | ||||||||||
| n | 9 (5, 18) | 12 (9, 18) | 1 (0, 5) | 1 (0, 3) | 4 (1, 9) | 5 (2, 10) | 1 (0, 3) | 1 (0, 4) | ||||||||||
| post_p | 0.82 (0.71, 0.91) | 0.87 (0.74, 0.98) | 0.59 (0.51, 0.72) | 0.64 (0.57, 0.77) | 0.64 (0.53, 0.88) | 0.7 (0.58, 0.92) | 0.65 (0.53, 0.78) | 0.56 (0.51, 0.79) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.048 (0, 0.086) | 0.026 (0, 0.048) | 0 (0, 0.102) | 0 (0, 0.084) | 0.068 (0, 0.141) | 0.012 (0, 0.073) | 0 (0, 0.101) | 0 (0, 0.129) | ||||||||||
| Carboplatin | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 12 (11, 21) | 12 (11, 21) | 12 (11, 21) | 12 (11, 21) | 12 (11, 21) | 12 (11, 21) | 12 (11, 21) | 12 (11, 21) | ||||||||||
| n | 14 (11, 14) | 5 (2, 10) | 1 (0, 3) | 2 (0, 3) | 4 (2, 4) | 0 (0, 2) | 3 (1, 5) | 3 (2, 4) | ||||||||||
| post_p | 0.85 (0.75, 0.9) | 0.55 (0.51, 0.79) | 0.73 (0.66, 0.81) | 0.73 (0.69, 0.77) | 0.51 (0.51, 0.59) | 0.62 (0.62, 0.62) | 0.57 (0.53, 0.58) | 0.63 (0.62, 0.82) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.065 (0.047, 0.085) | 0.036 (0.007, 0.076) | 0.061 (0.012, 0.11) | 0 (0, 0) | 0.081 (0.016, 0.109) | 0 (0, 0) | 0.06 (0.012, 0.061) | 0.067 (0.057, 0.1) | ||||||||||
| Niraparib | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | |||||||||
| time | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | 10 (8, 12) | ||||||||||
| n | 12 (9, 14) | 4 (4, 5) | 3 (2, 4) | 4 (2, 6) | 1 (0, 2) | 2 (2, 3) | 4 (4, 4) | 1 (1, 1) | ||||||||||
| post_p | 0.9 (0.88, 0.93) | 0.66 (0.56, 0.75) | 0.65 (0.63, 0.67) | 0.75 (0.74, 0.75) | 0.61 (0.61, 0.61) | 0.56 (0.54, 0.59) | 0.7 (0.7, 0.7) | 0.62 (0.54, 0.7) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.031 (0.006, 0.056) | 0.042 (0.008, 0.076) | 0.076 (0.015, 0.137) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.106 (0.085, 0.126) | 0 (0, 0) | ||||||||||
| DRD+ | Hormone_therapies | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | ||||||||
| time | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | 18 (14, 21) | ||||||||||
| n | 5 (3, 7) | 4 (3, 5) | 4 (2, 6) | 2 (2, 2) | 3 (2, 4) | 2 (1, 4) | 3 (2, 4) | 4 (3, 6) | ||||||||||
| post_p | 0.65 (0.58, 0.72) | 0.57 (0.54, 0.6) | 0.66 (0.56, 0.77) | 0.51 (0.51, 0.51) | 0.59 (0.59, 0.59) | 0.52 (0.52, 0.52) | 0.8 (0.7, 0.9) | 0.63 (0.53, 0.73) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.097 (0.084, 0.111) | 0.05 (0.01, 0.09) | 0.046 (0.009, 0.083) | 0.106 (0.084, 0.128) | 0.042 (0.008, 0.076) | 0.076 (0.076, 0.076) | 0.047 (0.009, 0.084) | 0.059 (0.031, 0.087) | ||||||||||
| Taxel_therapies | count | 20 | 20 | 20 | 20 | 20 | 20 | 20 | 20 | |||||||||
| time | 22 (18, 27) | 22 (18, 27) | 22 (18, 27) | 22 (18, 27) | 22 (18, 27) | 22 (18, 27) | 22 (18, 27) | 22 (18, 27) | ||||||||||
| n | 4 (2, 12) | 4 (2, 10) | 3 (1, 5) | 4 (0, 5) | 4 (1, 7) | 3 (1, 5) | 3 (0, 6) | 3 (0, 6) | ||||||||||
| post_p | 0.71 (0.52, 0.83) | 0.83 (0.71, 0.95) | 0.66 (0.52, 0.79) | 0.7 (0.55, 0.91) | 0.67 (0.59, 0.8) | 0.71 (0.54, 0.88) | 0.66 (0.53, 0.76) | 0.77 (0.54, 0.91) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.079 (0.026, 0.114) | 0.023 (0, 0.055) | 0.076 (0, 0.128) | 0.028 (0, 0.096) | 0.062 (0, 0.111) | 0.026 (0, 0.082) | 0.081 (0.013, 0.162) | 0.035 (0, 0.09) | ||||||||||
| Carboplatin | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | 10 (10, 10) | ||||||||||
| n | 8 (8, 8) | 5 (5, 5) | 4 (4, 4) | 0 (0, 0) | 3 (3, 3) | 2 (2, 2) | 4 (4, 4) | 4 (4, 4) | ||||||||||
| post_p | 0.83 (0.83, 0.83) | 0.98 (0.98, 0.98) | 0.73 (0.73, 0.73) | NA (NA, NA) | 0.53 (0.53, 0.53) | 0.57 (0.57, 0.57) | 0.58 (0.58, 0.58) | 0.63 (0.63, 0.63) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.049 (0.049, 0.049) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0.149 (0.149, 0.149) | 0.089 (0.089, 0.089) | 0.056 (0.056, 0.056) | 0 (0, 0) | ||||||||||
| TEfus+ | Taxel_therapies | count | 308 | 308 | 308 | 308 | 308 | 308 | 308 | 308 | ||||||||
| time | 15 (9, 29) | 15 (9, 29) | 15 (9, 29) | 15 (9, 29) | 15 (9, 29) | 15 (9, 29) | 15 (9, 29) | 15 (9, 29) | ||||||||||
| n | 7 (3, 16) | 15 (8, 35) | 3 (1, 12) | 2 (0, 7) | 6 (2, 13) | 5 (2, 12) | 2 (0, 7) | 2 (0, 7) | ||||||||||
| post_p | 0.78 (0.56, 0.97) | 0.88 (0.73, 0.99) | 0.72 (0.53, 0.92) | 0.65 (0.52, 0.86) | 0.75 (0.56, 0.93) | 0.76 (0.55, 0.93) | 0.66 (0.53, 0.86) | 0.66 (0.52, 0.89) | ||||||||||
| r_prob | 0.29 (0.29, 0.29) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.41 (0.41, 0.41) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.029 (0, 0.067) | 0.033 (0.013, 0.054) | 0 (0, 0.064) | 0 (0, 0.081) | 0.027 (0, 0.07) | 0.03 (0, 0.071) | 0 (0, 0.066) | 0 (0, 0.071) | ||||||||||
| Niraparib | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | |||||||||
| time | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | 12 (12, 12) | ||||||||||
| n | 2 (2, 2) | 2 (2, 2) | 10 (10, 10) | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | 2 (2, 2) | 3 (3, 3) | ||||||||||
| post_p | 0.67 (0.67, 0.67) | 0.57 (0.57, 0.57) | 0.71 (0.71, 0.71) | 0.51 (0.51, 0.51) | 0.6 (0.6, 0.6) | 0.57 (0.57, 0.57) | 0.77 (0.77, 0.77) | 0.72 (0.72, 0.72) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0 (0, 0) | 0 (0, 0) | 0.065 (0.065, 0.065) | 0.053 (0.053, 0.053) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | Hormone_therapies | count | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 | 18 |
| time | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | 10 (3, 29) | ||
| n | 20 (13, 46) | 3 (1, 5) | 10 (6, 30) | 4 (1, 5) | 0 (0, 4) | 0 (0, 3) | 0 (0, 3) | 1 (0, 3) | 2 (0, 7) | 2 (1, 5) | 1 (0, 4) | 1 (0, 5) | 0 (0, 4) | 0 (0, 7) | 0 (0, 2) | 0 (0, 3) | ||
| post_p | 0.27 (0.09, 0.41) | 0.35 (0.22, 0.42) | 0.33 (0.21, 0.44) | 0.32 (0.1, 0.46) | 0.39 (0.2, 0.49) | 0.29 (0.15, 0.44) | 0.3 (0.21, 0.48) | 0.4 (0.19, 0.49) | 0.32 (0.15, 0.46) | 0.32 (0.24, 0.43) | 0.32 (0.23, 0.48) | 0.33 (0.2, 0.46) | 0.38 (0.15, 0.47) | 0.36 (0.24, 0.4) | 0.32 (0.21, 0.4) | 0.37 (0.32, 0.46) | ||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||
| rate | 0.135 (0.1, 0.191) | 0.155 (0.03, 0.402) | 0.126 (0.088, 0.214) | 0.18 (0.088, 0.312) | 0.197 (0.086, 0.449) | 0.195 (0.11, 8.641) | 0.184 (0.079, 0.243) | 0.128 (0.072, 0.3) | 0.266 (0.109, 0.956) | 0.139 (0, 0.271) | 0.191 (0.101, 1.29) | 0.176 (0.009, 0.743) | 0.174 (0.059, 0.561) | 0.168 (0.063, 0.545) | 0.339 (0.255, 1.021) | 0.156 (0.057, 1.486) | ||
| Niraparib | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | |
| time | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | ||
| n | 19 (9, 30) | 4 (1, 11) | 12 (8, 18) | 13 (6, 17) | 4 (2, 6) | 3 (2, 7) | 5 (1, 8) | 4 (1, 10) | 2 (0, 6) | 4 (2, 8) | 2 (1, 6) | 4 (2, 7) | 3 (2, 7) | 3 (2, 4) | 3 (3, 5) | 3 (2, 4) | ||
| post_p | 0.41 (0.23, 0.47) | 0.31 (0.11, 0.4) | 0.25 (0.16, 0.4) | 0.4 (0.28, 0.42) | 0.35 (0.21, 0.49) | 0.31 (0.25, 0.44) | 0.43 (0.22, 0.44) | 0.43 (0.27, 0.49) | 0.42 (0.38, 0.46) | 0.42 (0.27, 0.48) | 0.31 (0.18, 0.46) | 0.24 (0.16, 0.36) | 0.19 (0.14, 0.3) | 0.17 (0.13, 0.28) | 0.39 (0.18, 0.39) | 0.37 (0.19, 0.49) | ||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||
| rate | 0.125 (0.118, 0.181) | 0.127 (0.07, 0.155) | 0.134 (0.123, 0.16) | 0.102 (0.084, 0.186) | 0.198 (0.11, 0.829) | 0.129 (0.126, 0.135) | 0.203 (0.141, 0.273) | 0.103 (0.089, 0.381) | 0.139 (0.092, 0.699) | 0.1 (0.085, 0.147) | 0.287 (0.163, 0.595) | 0.182 (0.14, 1.748) | 0.409 (0.195, 1.03) | 0.194 (0.175, 0.201) | 0.161 (0.142, 0.254) | 0.181 (0.155, 0.391) | ||
| TP53- & AR- | Hormone_therapies | count | 259 | 259 | 259 | 259 | ||||||||||||
| time | 17 (8, 31) | 17 (8, 31) | 17 (8, 31) | 17 (8, 31) | ||||||||||||||
| n | 25 (17, 65) | 5 (2, 10) | 3 (0, 8) | 3 (0, 9) | ||||||||||||||
| post_p | 0.34 (0.12, 0.47) | 0.32 (0.14, 0.46) | 0.38 (0.23, 0.48) | 0.35 (0.16, 0.48) | ||||||||||||||
| r_prob | 0.44 (0.44, 0.44) | 0.35 (0.35, 0.35) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.125 (0.105, 0.166) | 0.137 (0.072, 0.325) | 0.164 (0.092, 0.529) | 0.148 (0.076, 0.563) | ||||||||||||||
| Taxel_therapies | count | 11 | 11 | 11 | 11 | |||||||||||||
| time | 17 (13, 22) | 17 (13, 22) | 17 (13, 22) | 17 (13, 22) | ||||||||||||||
| n | 23 (13, 35) | 5 (2, 9) | 4 (0, 5) | 2 (1, 4) | ||||||||||||||
| post_p | 0.35 (0.24, 0.45) | 0.32 (0.27, 0.41) | 0.42 (0.24, 0.44) | 0.44 (0.32, 0.47) | ||||||||||||||
| r_prob | 0.11 (0.11, 0.11) | 0.29 (0.29, 0.29) | 0 (0, 0) | 0 (0, 0) | ||||||||||||||
| rate | 0.143 (0.107, 0.152) | 0.114 (0.078, 0.312) | 0.152 (0.094, 0.31) | 0.125 (0.063, 0.521) | ||||||||||||||
| Carboplatin | count | 205 | 205 | 205 | 205 | |||||||||||||
| time | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | ||||||||||||||
| n | 17 (8, 65) | 4 (2, 13) | 6 (2, 16) | 6 (3, 15) | ||||||||||||||
| post_p | 0.33 (0.11, 0.48) | 0.32 (0.13, 0.45) | 0.37 (0.17, 0.48) | 0.31 (0.12, 0.48) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.131 (0.105, 0.198) | 0.145 (0.091, 0.423) | 0.145 (0.103, 0.402) | 0.13 (0.083, 0.3) | ||||||||||||||
| Niraparib | count | 236 | 236 | 236 | 236 | |||||||||||||
| time | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | ||||||||||||||
| n | 22 (9, 58) | 4 (1, 12) | 6 (2, 14) | 6 (2, 13) | ||||||||||||||
| post_p | 0.36 (0.13, 0.47) | 0.32 (0.14, 0.46) | 0.38 (0.16, 0.49) | 0.27 (0.1, 0.44) | ||||||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||||||
| rate | 0.128 (0.106, 0.197) | 0.141 (0.084, 0.418) | 0.159 (0.104, 0.417) | 0.148 (0.091, 0.378) | ||||||||||||||
| TP53+ | Hormone_therapies | count | 70 | 70 | 70 | 70 | 70 | 70 | 70 | 70 | ||||||||
| time | 22 (10, 33) | 22 (10, 33) | 22 (10, 33) | 22 (10, 33) | 22 (10, 33) | 22 (10, 33) | 22 (10, 33) | 22 (10, 33) | ||||||||||
| n | 14 (6, 35) | 8 (3, 14) | 2 (0, 6) | 2 (1, 8) | 3 (1, 7) | 3 (1, 10) | 2 (0, 5) | 2 (1, 6) | ||||||||||
| post_p | 0.3 (0.1, 0.46) | 0.24 (0.07, 0.45) | 0.38 (0.18, 0.49) | 0.34 (0.17, 0.48) | 0.34 (0.15, 0.47) | 0.33 (0.18, 0.48) | 0.35 (0.26, 0.48) | 0.36 (0.18, 0.48) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.12 (0.12, 0.12) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.129 (0.102, 0.242) | 0.129 (0.089, 0.304) | 0.176 (0.077, 0.6) | 0.162 (0.089, 0.556) | 0.197 (0.108, 0.892) | 0.14 (0.083, 0.658) | 0.213 (0.12, 0.666) | 0.18 (0.042, 0.751) | ||||||||||
| Taxel_therapies | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | |||||||||
| time | 10 (7, 16) | 10 (7, 16) | 10 (7, 16) | 10 (7, 16) | 10 (7, 16) | 10 (7, 16) | 10 (7, 16) | 10 (7, 16) | ||||||||||
| n | 11 (9, 17) | 9 (8, 9) | 2 (0, 3) | 0 (0, 1) | 6 (1, 6) | 4 (3, 9) | 0 (0, 2) | 0 (0, 3) | ||||||||||
| post_p | 0.4 (0.2, 0.44) | 0.44 (0.24, 0.48) | 0.32 (0.28, 0.36) | 0.5 (0.5, 0.5) | 0.14 (0.08, 0.19) | 0.38 (0.23, 0.43) | 0.49 (0.49, 0.49) | 0.37 (0.37, 0.37) | ||||||||||
| r_prob | 0.17 (0.17, 0.17) | 0.41 (0.41, 0.41) | 0 (0, 0) | 0 (0, 0) | 0.37 (0.37, 0.37) | 0.37 (0.37, 0.37) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.128 (0.118, 0.134) | 0.085 (0.054, 0.09) | 0.178 (0.036, 0.321) | 0 (0, 0) | 0.184 (0.143, 0.225) | 0.082 (0.069, 0.153) | 0.27 (0.27, 0.27) | 0.129 (0.129, 0.129) | ||||||||||
| Carboplatin | count | 61 | 61 | 61 | 61 | 61 | 61 | 61 | 61 | |||||||||
| time | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | 22 (14, 33) | ||||||||||
| n | 12 (3, 35) | 8 (4, 23) | 3 (1, 9) | 4 (1, 7) | 3 (1, 8) | 4 (1, 9) | 3 (1, 8) | 3 (1, 8) | ||||||||||
| post_p | 0.3 (0.14, 0.48) | 0.24 (0.08, 0.44) | 0.33 (0.21, 0.48) | 0.38 (0.18, 0.49) | 0.36 (0.22, 0.48) | 0.36 (0.18, 0.48) | 0.38 (0.22, 0.47) | 0.32 (0.16, 0.45) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.141 (0.111, 0.422) | 0.126 (0.086, 0.263) | 0.211 (0.107, 0.609) | 0.152 (0.085, 0.39) | 0.174 (0.103, 0.766) | 0.14 (0.07, 0.698) | 0.18 (0.111, 0.482) | 0.176 (0.082, 0.597) | ||||||||||
| Niraparib | count | 75 | 75 | 75 | 75 | 75 | 75 | 75 | 75 | |||||||||
| time | 22 (12, 32) | 22 (12, 32) | 22 (12, 32) | 22 (12, 32) | 22 (12, 32) | 22 (12, 32) | 22 (12, 32) | 22 (12, 32) | ||||||||||
| n | 10 (5, 23) | 5 (2, 16) | 3 (1, 7) | 4 (1, 8) | 3 (1, 7) | 3 (1, 8) | 3 (1, 6) | 3 (1, 7) | ||||||||||
| post_p | 0.34 (0.11, 0.47) | 0.32 (0.1, 0.47) | 0.37 (0.19, 0.48) | 0.3 (0.13, 0.45) | 0.35 (0.23, 0.48) | 0.35 (0.17, 0.46) | 0.34 (0.2, 0.48) | 0.34 (0.18, 0.48) | ||||||||||
| r_prob | 0.08 (0.08, 0.08) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.135 (0.104, 0.244) | 0.127 (0.08, 0.459) | 0.197 (0.104, 0.479) | 0.192 (0.089, 0.436) | 0.185 (0.102, 0.915) | 0.16 (0.086, 0.958) | 0.205 (0.103, 0.982) | 0.155 (0.076, 0.414) | ||||||||||
| DRD+ | Hormone_therapies | count | 45 | 45 | 45 | 45 | 45 | 45 | 45 | 45 | ||||||||
| time | 30 (19, 34) | 30 (19, 34) | 30 (19, 34) | 30 (19, 34) | 30 (19, 34) | 30 (19, 34) | 30 (19, 34) | 30 (19, 34) | ||||||||||
| n | 4 (1, 9) | 5 (1, 14) | 3 (1, 8) | 3 (1, 9) | 4 (2, 7) | 3 (1, 7) | 3 (1, 9) | 4 (1, 9) | ||||||||||
| post_p | 0.34 (0.16, 0.48) | 0.28 (0.14, 0.46) | 0.34 (0.19, 0.48) | 0.32 (0.14, 0.43) | 0.4 (0.24, 0.49) | 0.37 (0.12, 0.46) | 0.36 (0.21, 0.48) | 0.35 (0.21, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.168 (0.114, 0.406) | 0.143 (0.088, 0.37) | 0.201 (0.106, 2.566) | 0.165 (0.091, 0.806) | 0.169 (0.1, 0.434) | 0.159 (0.086, 0.619) | 0.179 (0.11, 0.965) | 0.139 (0.082, 0.626) | ||||||||||
| Carboplatin | count | 48 | 48 | 48 | 48 | 48 | 48 | 48 | 48 | |||||||||
| time | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | 26 (14, 35) | ||||||||||
| n | 6 (2, 14) | 6 (3, 12) | 3 (1, 7) | 4 (2, 8) | 3 (1, 9) | 4 (2, 9) | 3 (2, 8) | 4 (1, 10) | ||||||||||
| post_p | 0.36 (0.18, 0.49) | 0.28 (0.1, 0.44) | 0.34 (0.22, 0.47) | 0.35 (0.14, 0.47) | 0.35 (0.21, 0.48) | 0.33 (0.15, 0.47) | 0.38 (0.18, 0.48) | 0.35 (0.18, 0.46) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.155 (0.098, 0.458) | 0.119 (0.088, 0.269) | 0.2 (0.115, 0.68) | 0.127 (0.072, 0.343) | 0.184 (0.109, 0.687) | 0.148 (0.091, 0.385) | 0.189 (0.099, 0.474) | 0.136 (0.085, 0.371) | ||||||||||
| Niraparib | count | 74 | 74 | 74 | 74 | 74 | 74 | 74 | 74 | |||||||||
| time | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | ||||||||||
| n | 6 (2, 12) | 7 (3, 13) | 3 (1, 8) | 3 (1, 8) | 3 (1, 8) | 4 (1, 7) | 3 (1, 7) | 3 (1, 7) | ||||||||||
| post_p | 0.36 (0.16, 0.48) | 0.27 (0.13, 0.44) | 0.35 (0.21, 0.46) | 0.31 (0.15, 0.46) | 0.35 (0.21, 0.47) | 0.32 (0.16, 0.46) | 0.37 (0.17, 0.47) | 0.32 (0.14, 0.45) | ||||||||||
| r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.152 (0.107, 0.317) | 0.131 (0.087, 0.39) | 0.171 (0.097, 0.546) | 0.157 (0.086, 0.492) | 0.171 (0.113, 0.415) | 0.159 (0.088, 0.393) | 0.188 (0.106, 0.835) | 0.165 (0.087, 0.543) | ||||||||||
| TEfus+ | Hormone_therapies | count | 207 | 207 | 207 | 207 | 207 | 207 | 207 | 207 | ||||||||
| time | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | 25 (16, 34) | ||||||||||
| n | 5 (2, 11) | 8 (4, 22) | 4 (1, 12) | 3 (1, 7) | 4 (2, 11) | 4 (1, 10) | 3 (1, 7) | 3 (1, 8) | ||||||||||
| post_p | 0.28 (0.13, 0.45) | 0.21 (0.06, 0.44) | 0.32 (0.14, 0.48) | 0.34 (0.17, 0.47) | 0.32 (0.15, 0.47) | 0.31 (0.14, 0.47) | 0.34 (0.19, 0.48) | 0.36 (0.19, 0.46) | ||||||||||
| r_prob | 0.35 (0.35, 0.35) | 0.18 (0.18, 0.18) | 0 (0, 0) | 0 (0, 0) | 0.18 (0.18, 0.18) | 0.12 (0.12, 0.12) | 0 (0, 0) | 0 (0, 0) | ||||||||||
| rate | 0.145 (0.082, 0.313) | 0.125 (0.085, 0.267) | 0.138 (0.084, 0.452) | 0.155 (0.084, 0.509) | 0.138 (0.085, 0.446) | 0.141 (0.087, 0.551) | 0.167 (0.086, 0.652) | 0.147 (0.085, 0.491) | ||||||||||
| Carboplatin | count | 228 | 228 | 228 | 228 | 228 | 228 | 228 | 228 | |||||||||
| time | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | 26 (17, 34) | ||||||||||
| n | 5 (2, 13) | 8 (3, 24) | 7 (3, 16) | 4 (2, 11) | 4 (1, 10) | 4 (1, 9) | 4 (2, 9) | 4 (2, 9) | ||||||||||
| post_p | 0.32 (0.14, 0.46) | 0.24 (0.08, 0.48) | 0.3 (0.11, 0.48) | 0.35 (0.14, 0.47) | 0.31 (0.15, 0.46) | 0.3 (0.15, 0.44) | 0.33 (0.15, 0.47) | 0.32 (0.16, 0.47) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.137 (0.08, 0.388) | 0.119 (0.079, 0.291) | 0.122 (0.083, 0.268) | 0.139 (0.087, 0.418) | 0.144 (0.085, 0.514) | 0.153 (0.085, 0.498) | 0.148 (0.086, 0.45) | 0.142 (0.084, 0.396) | ||||||||||
| Niraparib | count | 215 | 215 | 215 | 215 | 215 | 215 | 215 | 215 | |||||||||
| time | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | 24 (16, 34) | ||||||||||
| n | 4 (1, 14) | 7 (3, 22) | 6 (2, 15) | 4 (2, 10) | 4 (1, 10) | 4 (1, 9) | 4 (1, 8) | 4 (2, 8) | ||||||||||
| post_p | 0.3 (0.15, 0.44) | 0.24 (0.08, 0.46) | 0.3 (0.1, 0.47) | 0.33 (0.16, 0.46) | 0.33 (0.17, 0.47) | 0.33 (0.16, 0.45) | 0.33 (0.17, 0.46) | 0.36 (0.2, 0.48) | ||||||||||
| r_prob | 0 (0, 0) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||||
| rate | 0.142 (0.088, 0.568) | 0.13 (0.082, 0.314) | 0.133 (0.085, 0.349) | 0.143 (0.087, 0.394) | 0.138 (0.083, 0.393) | 0.143 (0.083, 0.495) | 0.158 (0.084, 0.506) | 0.142 (0.081, 0.293) |