Simulation scenario 5

Setting description

Taxel_therapies more effective in the TEfus+ biomarker signature

Simulations setting

PFS distributions

Treatment effects

By subgroup:

subtype	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
—+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
–+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
–++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-+–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
-++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
-+++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+—	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+–+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+-+-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
+-++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
++–	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++-+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1
+++-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1	af = 1, hr = 1
++++	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1

By signature:

signature	var	Other	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1, hr = 1	af = 1, hr = 1
TP53- & AR-	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1, hr = 1	af = 1, hr = 1
TP53+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1, hr = 1	af = 1, hr = 1
DRD+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.075, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 13.1, median = 9.4	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 1.49, hr = 0.66	af = 1, hr = 1	af = 1, hr = 1
TEfus+	param	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.037, shape = 1.05	scale = 0.112, shape = 1.05	scale = 0.112, shape = 1.05
	summary	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3	mean = 26.6, median = 19.1	mean = 8.8, median = 6.3	mean = 8.8, median = 6.3
	effect	af = 1, hr = 1	af = 1, hr = 1	af = 3.03, hr = 0.31	af = 1, hr = 1	af = 1, hr = 1

Errors and power

graduation (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 5 21 1 1 TP53- & AR- 29 115 9 9 TP53+ 1 31 3 2 DRD+ 2 20 1 0 TEfus+ 0 308 0 1

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.010 0.042 0.002 0.002 TP53- & AR- 0.058 0.230 0.018 0.018 TP53+ 0.002 0.062 0.006 0.004 DRD+ 0.004 0.040 0.002 0.000 TEfus+ 0.000 0.616 0.000 0.002

futility (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 18 0 0 4 TP53- & AR- 259 11 205 236 TP53+ 70 3 61 75 DRD+ 45 0 48 74 TEfus+ 207 0 228 215

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.036 0.000 0.000 0.008 TP53- & AR- 0.518 0.022 0.410 0.472 TP53+ 0.140 0.006 0.122 0.150 DRD+ 0.090 0.000 0.096 0.148 TEfus+ 0.414 0.000 0.456 0.430

max sample size (counts and proportions):

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0 0 0 0 TP53- & AR- 18 11 19 11 TP53+ 7 26 8 8 DRD+ 0 0 0 0 TEfus+ 2 21 2 2

Hormone_therapies Taxel_therapies Carboplatin Niraparib all 0.000 0.000 0.000 0.000 TP53- & AR- 0.036 0.022 0.038 0.022 TP53+ 0.014 0.052 0.016 0.016 DRD+ 0.000 0.000 0.000 0.000 TEfus+ 0.004 0.042 0.004 0.004

Errors & power

The overall error was 0.22.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.072             0.112             0.028             0.026 

The overall power was 0.616.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.616             0.000             0.000 

Median results at the end of the trial

By signature:

signature	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	graduation	0	5	21	1	1
	futility	0	18	0	0	4
	max_n	0	0	0	0	0
	n	432 (394, 467)	170 (108, 250)	187 (104, 269)	180 (119, 253)	173 (113, 239)
	n_unique	399 (364, 430)	157 (99, 231)	171 (94, 251)	168 (108, 237)	160 (102, 221)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)
	time_stop	NA (NA, NA)	7 (3, 29)	6 (5, 15)	11 (11, 11)	18 (9, 35)
	post_p	NA (NA, NA)	0.06 (0, 0.37)	1 (0.91, 1)	0.07 (0, 0.39)	0.05 (0, 0.38)
	rate	0.096 (0.089, 0.103)	0.113 (0.102, 0.128)	0.067 (0.057, 0.083)	0.112 (0.101, 0.126)	0.113 (0.101, 0.128)
TP53- & AR-	graduation	0	29	115	9	9
	futility	0	259	11	205	236
	max_n	0	18	11	19	11
	n	177 (153, 201)	61 (26, 130)	60 (26, 119)	69 (27, 132)	64 (27, 117)
	n_unique	165 (141, 188)	57 (25, 123)	54 (24, 112)	64 (24, 123)	58 (24, 110)
	time_trial	36 (36, 36)	28 (9, 36)	36 (14, 36)	36 (16, 36)	36 (15, 36)
	time_stop	NA (NA, NA)	15 (7, 30)	16 (10, 28)	22 (13, 33)	22 (13, 33)
	post_p	NA (NA, NA)	0.25 (0.04, 0.73)	0.94 (0.48, 1)	0.26 (0.03, 0.72)	0.22 (0.03, 0.69)
	rate	0.101 (0.091, 0.114)	0.115 (0.096, 0.142)	0.078 (0.058, 0.103)	0.113 (0.096, 0.144)	0.117 (0.098, 0.147)
TP53+	graduation	0	1	31	3	2
	futility	0	70	3	61	75
	max_n	0	7	26	8	8
	n	194 (172, 216)	79 (36, 116)	90 (41, 137)	81 (45, 118)	79 (40, 116)
	n_unique	178 (156, 199)	72 (34, 108)	83 (38, 128)	74 (41, 108)	73 (36, 108)
	time_trial	36 (36, 36)	36 (28, 36)	36 (36, 36)	36 (31, 36)	36 (24, 36)
	time_stop	NA (NA, NA)	22 (10, 33)	10 (7, 20)	22 (13, 33)	21 (12, 32)
	post_p	NA (NA, NA)	0.1 (0.01, 0.47)	1 (0.84, 1)	0.11 (0.01, 0.46)	0.1 (0.01, 0.48)
	rate	0.093 (0.083, 0.104)	0.114 (0.098, 0.138)	0.062 (0.049, 0.079)	0.114 (0.097, 0.136)	0.115 (0.097, 0.138)
DRD+	graduation	0	2	20	1	0
	futility	0	45	0	48	74
	max_n	0	0	0	0	0
	n	117 (100, 133)	42 (25, 66)	42 (20, 74)	59 (38, 84)	55 (35, 82)
	n_unique	107 (90, 122)	38 (22, 61)	38 (18, 68)	54 (35, 79)	51 (31, 76)
	time_trial	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (36, 36)	36 (28, 36)
	time_stop	NA (NA, NA)	28 (19, 34)	22 (18, 27)	25 (14, 35)	24 (16, 34)
	post_p	NA (NA, NA)	0.18 (0.02, 0.62)	0.94 (0.54, 1)	0.13 (0.02, 0.56)	0.12 (0.01, 0.49)
	rate	0.091 (0.078, 0.105)	0.113 (0.089, 0.147)	0.064 (0.048, 0.093)	0.113 (0.095, 0.138)	0.117 (0.095, 0.144)
TEfus+	graduation	0	0	308	0	1
	futility	0	207	0	228	215
	max_n	0	2	21	2	2
	n	163 (143, 183)	51 (27, 94)	72 (26, 141)	59 (32, 97)	54 (29, 101)
	n_unique	150 (130, 169)	46 (24, 87)	65 (25, 128)	54 (29, 88)	49 (27, 92)
	time_trial	36 (36, 36)	36 (19, 36)	24 (10, 36)	36 (20, 36)	36 (19, 36)
	time_stop	NA (NA, NA)	25 (16, 34)	15 (9, 29)	26 (17, 34)	24 (16, 34)
	post_p	NA (NA, NA)	0.02 (0, 0.18)	1 (1, 1)	0.01 (0, 0.15)	0.02 (0, 0.15)
	rate	0.074 (0.065, 0.086)	0.115 (0.095, 0.145)	0.036 (0.029, 0.044)	0.114 (0.095, 0.14)	0.115 (0.095, 0.143)

By subgroup combinations:

subtype	var	Control	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
—-	graduation	0	299	144	215	247
	futility	0	0	0	0	0
	max_n	0	18	11	19	11
	n	113 (93, 134)	39 (17, 99)	31 (10, 82)	38 (9, 90)	32 (10, 84)
	n_unique	105 (85, 126)	37 (17, 94)	29 (9, 77)	36 (8, 86)	30 (9, 78)
	post_p	NA (NA, NA)	0.47 (0.11, 0.89)	0.43 (0.09, 0.88)	0.47 (0.09, 0.89)	0.42 (0.09, 0.89)
	rate	0.112 (0.099, 0.129)	0.116 (0.094, 0.153)	0.116 (0.091, 0.18)	0.116 (0.093, 0.184)	0.119 (0.093, 0.18)
—+	graduation	0	368	364	333	350
	futility	0	0	0	0	0
	max_n	0	19	31	20	12
	n	21 (14, 28)	6 (2, 16)	8 (3, 22)	6 (2, 17)	5 (2, 17)
	n_unique	19 (12, 26)	5 (2, 14)	7 (2, 21)	5 (1, 16)	5 (1, 15)
	post_p	NA (NA, NA)	0.27 (0.09, 0.55)	0.92 (0.58, 1)	0.26 (0.11, 0.55)	0.28 (0.1, 0.57)
	rate	0.074 (0.05, 0.111)	0.127 (0.076, 0.297)	0.036 (0.02, 0.07)	0.127 (0.078, 0.356)	0.134 (0.08, 0.381)
–+-	graduation	0	85	54	65	78
	futility	0	0	0	0	0
	max_n	0	7	26	8	8
	n	63 (50, 77)	25 (8, 59)	22 (7, 53)	24 (6, 52)	24 (7, 53)
	n_unique	58 (44, 72)	24 (8, 55)	21 (6, 49)	22 (6, 50)	23 (6, 49)
	post_p	NA (NA, NA)	0.44 (0.09, 0.89)	0.48 (0.13, 0.88)	0.44 (0.11, 0.87)	0.46 (0.12, 0.86)
	rate	0.114 (0.094, 0.14)	0.117 (0.093, 0.196)	0.118 (0.087, 0.193)	0.122 (0.091, 0.235)	0.121 (0.089, 0.212)
–++	graduation	0	247	330	261	251
	futility	0	0	0	0	0
	max_n	0	9	43	9	8
	n	47 (36, 57)	10 (4, 31)	22 (9, 50)	11 (3, 32)	10 (3, 29)
	n_unique	43 (33, 54)	9 (3, 30)	21 (8, 46)	10 (3, 30)	9 (3, 27)
	post_p	NA (NA, NA)	0.18 (0.04, 0.44)	0.99 (0.84, 1)	0.21 (0.05, 0.5)	0.19 (0.06, 0.49)
	rate	0.075 (0.058, 0.096)	0.123 (0.084, 0.241)	0.036 (0.025, 0.052)	0.118 (0.078, 0.25)	0.123 (0.079, 0.258)
-+–	graduation	0	320	158	235	269
	futility	0	0	0	0	0
	max_n	0	18	11	19	11
	n	21 (14, 28)	5 (1, 16)	6 (1, 18)	10 (3, 22)	9 (3, 22)
	n_unique	19 (13, 26)	4 (1, 15)	5 (1, 16)	9 (3, 21)	8 (2, 20)
	post_p	NA (NA, NA)	0.48 (0.21, 0.83)	0.48 (0.16, 0.84)	0.45 (0.17, 0.84)	0.43 (0.17, 0.85)
	rate	0.113 (0.084, 0.16)	0.125 (0.071, 0.36)	0.122 (0.07, 0.332)	0.125 (0.081, 0.289)	0.128 (0.079, 0.307)
-+-+	graduation	0	381	366	339	359
	futility	0	0	0	0	0
	max_n	0	19	31	20	12
	n	21 (14, 29)	5 (1, 16)	5 (1, 20)	8 (3, 19)	7 (2, 19)
	n_unique	19 (12, 26)	4 (1, 15)	5 (1, 19)	8 (3, 18)	7 (2, 17)
	post_p	NA (NA, NA)	0.3 (0.11, 0.6)	0.88 (0.51, 0.99)	0.26 (0.09, 0.59)	0.25 (0.1, 0.53)
	rate	0.076 (0.053, 0.111)	0.131 (0.073, 0.431)	0.036 (0.013, 0.082)	0.119 (0.076, 0.255)	0.125 (0.082, 0.336)
-++-	graduation	0	121	71	98	123
	futility	0	0	0	0	0
	max_n	0	7	26	8	7
	n	12 (7, 17)	4 (1, 10)	4 (1, 10)	6 (2, 13)	5 (2, 12)
	n_unique	11 (6, 16)	4 (1, 9)	3 (1, 9)	5 (2, 12)	5 (2, 12)
	post_p	NA (NA, NA)	0.46 (0.23, 0.83)	0.45 (0.23, 0.79)	0.46 (0.21, 0.82)	0.44 (0.21, 0.8)
	rate	0.114 (0.073, 0.17)	0.125 (0.064, 0.386)	0.132 (0.068, 0.396)	0.125 (0.071, 0.343)	0.135 (0.073, 0.358)
-+++	graduation	0	263	332	272	264
	futility	0	0	0	0	0
	max_n	0	9	43	9	8
	n	13 (8, 18)	4 (1, 11)	3 (0, 11)	5 (2, 12)	5 (2, 13)
	n_unique	11 (7, 16)	4 (1, 10)	3 (0, 10)	5 (2, 11)	4 (2, 12)
	post_p	NA (NA, NA)	0.35 (0.17, 0.61)	0.78 (0.41, 0.96)	0.32 (0.14, 0.62)	0.31 (0.13, 0.63)
	rate	0.074 (0.045, 0.123)	0.128 (0.07, 0.396)	0.042 (0, 0.126)	0.132 (0.071, 0.326)	0.131 (0.071, 0.345)
+—	graduation	0	23	21	1	5
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	20 (14, 27)	9 (2, 18)	10 (3, 20)	8 (3, 17)	8 (2, 17)
	n_unique	18 (12, 25)	8 (2, 16)	10 (3, 19)	7 (2, 16)	7 (2, 15)
	post_p	NA (NA, NA)	0.43 (0.18, 0.84)	0.46 (0.16, 0.84)	0.47 (0.19, 0.86)	0.48 (0.19, 0.82)
	rate	0.115 (0.082, 0.157)	0.128 (0.078, 0.342)	0.124 (0.081, 0.27)	0.121 (0.074, 0.308)	0.12 (0.073, 0.323)
+–+	graduation	0	221	324	229	218
	futility	0	0	0	0	0
	max_n	0	2	21	2	2
	n	17 (12, 24)	5 (2, 14)	8 (3, 18)	5 (2, 13)	5 (2, 13)
	n_unique	16 (11, 22)	4 (2, 13)	7 (2, 17)	4 (1, 12)	4 (1, 12)
	post_p	NA (NA, NA)	0.29 (0.14, 0.55)	0.88 (0.58, 0.99)	0.3 (0.12, 0.58)	0.31 (0.14, 0.62)
	rate	0.075 (0.046, 0.11)	0.128 (0.078, 0.374)	0.038 (0.02, 0.072)	0.131 (0.071, 0.359)	0.128 (0.069, 0.365)
+-+-	graduation	0	85	54	65	78
	futility	0	0	0	0	0
	max_n	0	7	26	8	8
	n	16 (11, 22)	6 (2, 15)	8 (3, 17)	6 (2, 15)	6 (2, 15)
	n_unique	15 (10, 20)	6 (1, 14)	7 (2, 15)	6 (2, 14)	6 (2, 14)
	post_p	NA (NA, NA)	0.45 (0.19, 0.83)	0.48 (0.17, 0.84)	0.45 (0.19, 0.81)	0.45 (0.2, 0.82)
	rate	0.114 (0.078, 0.164)	0.128 (0.073, 0.391)	0.124 (0.075, 0.294)	0.13 (0.077, 0.553)	0.129 (0.073, 0.432)
+-++	graduation	0	247	330	261	251
	futility	0	0	0	0	0
	max_n	0	9	43	9	8
	n	17 (12, 24)	5 (2, 14)	7 (2, 19)	5 (2, 13)	5 (2, 13)
	n_unique	16 (10, 22)	5 (1, 12)	7 (2, 17)	5 (1, 12)	4 (1, 12)
	post_p	NA (NA, NA)	0.27 (0.13, 0.58)	0.89 (0.56, 0.99)	0.3 (0.12, 0.55)	0.3 (0.12, 0.59)
	rate	0.076 (0.049, 0.113)	0.133 (0.075, 0.358)	0.037 (0.016, 0.074)	0.133 (0.074, 0.382)	0.133 (0.065, 0.375)
++–	graduation	0	67	41	50	77
	futility	0	0	0	0	0
	max_n	0	0	0	0	0
	n	11 (7, 17)	5 (1, 11)	4 (1, 10)	6 (2, 13)	5 (2, 12)
	n_unique	11 (6, 16)	4 (1, 10)	4 (1, 9)	6 (2, 12)	5 (2, 11)
	post_p	NA (NA, NA)	0.48 (0.23, 0.82)	0.44 (0.22, 0.8)	0.46 (0.2, 0.84)	0.43 (0.21, 0.82)
	rate	0.114 (0.071, 0.175)	0.125 (0.058, 0.41)	0.13 (0.066, 0.53)	0.128 (0.071, 0.36)	0.133 (0.074, 0.374)
++-+	graduation	0	238	327	243	246
	futility	0	0	0	0	0
	max_n	0	2	21	2	2
	n	12 (8, 18)	4 (1, 11)	3 (0, 11)	5 (2, 12)	5 (2, 12)
	n_unique	11 (7, 16)	3 (1, 9)	3 (0, 10)	5 (1, 11)	4 (2, 11)
	post_p	NA (NA, NA)	0.34 (0.16, 0.64)	0.79 (0.44, 0.96)	0.32 (0.14, 0.63)	0.31 (0.13, 0.61)
	rate	0.074 (0.043, 0.125)	0.132 (0.067, 0.539)	0.04 (0.007, 0.105)	0.129 (0.072, 0.375)	0.136 (0.074, 0.359)
+++-	graduation	0	121	71	98	123
	futility	0	0	0	0	0
	max_n	0	7	26	8	7
	n	12 (7, 17)	4 (1, 11)	4 (1, 10)	6 (2, 13)	5 (2, 12)
	n_unique	11 (6, 16)	4 (1, 10)	4 (1, 9)	5 (2, 12)	5 (2, 12)
	post_p	NA (NA, NA)	0.44 (0.22, 0.8)	0.45 (0.2, 0.79)	0.48 (0.22, 0.83)	0.43 (0.2, 0.8)
	rate	0.114 (0.07, 0.184)	0.135 (0.069, 0.454)	0.133 (0.067, 0.418)	0.122 (0.075, 0.355)	0.133 (0.075, 0.462)
++++	graduation	0	263	332	272	264
	futility	0	0	0	0	0
	max_n	0	9	43	9	8
	n	12 (8, 18)	4 (1, 11)	3 (0, 11)	5 (2, 12)	5 (2, 12)
	n_unique	11 (7, 17)	4 (1, 10)	3 (0, 10)	5 (2, 11)	4 (2, 11)
	post_p	NA (NA, NA)	0.35 (0.17, 0.68)	0.81 (0.47, 0.96)	0.32 (0.14, 0.63)	0.33 (0.15, 0.7)
	rate	0.079 (0.047, 0.131)	0.13 (0.063, 0.393)	0.036 (0, 0.111)	0.13 (0.071, 0.36)	0.126 (0.069, 0.317)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	5	21	1	1
	time_stop	6 (4, 8)	6 (5, 15)	11 (11, 11)	7 (7, 7)
	n_trt	31 (28, 50)	38 (29, 75)	58 (58, 58)	34 (34, 34)
	n_control	64 (50, 95)	71 (54, 158)	114 (114, 114)	64 (64, 64)
	post_p	0.92 (0.9, 0.98)	0.98 (0.92, 1)	0.98 (0.98, 0.98)	0.94 (0.94, 0.94)
	order	1 (1, 2.6)	1 (1, 2)	1 (1, 1)	1 (1, 1)
TP53- & AR-	count	29	115	9	9
	time_stop	10 (6, 14)	16 (10, 30)	13 (9, 19)	12 (9, 13)
	n_trt	30 (25, 50)	34 (25, 68)	28 (25, 53)	28 (27, 36)
	n_control	36 (25, 60)	68 (40, 136)	55 (47, 85)	49 (40, 61)
	post_p	0.9 (0.86, 0.98)	0.96 (0.88, 1)	0.9 (0.89, 0.95)	0.93 (0.87, 0.97)
	order	1 (1, 1)	1 (1, 2)	1 (1, 2.2)	1 (1, 2)
TP53+	count	1	31	3	2
	time_stop	8 (8, 8)	10 (8, 21)	12 (11, 21)	10 (8, 12)
	n_trt	26 (26, 26)	34 (26, 64)	31 (26, 37)	32 (30, 33)
	n_control	33 (33, 33)	52 (31, 122)	62 (48, 108)	46 (36, 56)
	post_p	0.88 (0.88, 0.88)	0.99 (0.94, 1)	0.93 (0.89, 0.97)	0.97 (0.95, 0.99)
	order	1 (1, 1)	1 (1, 2)	2 (1.2, 2)	1.5 (1.1, 1.9)
DRD+	count	2	20	1
	time_stop	18 (14, 21)	22 (18, 27)	10 (10, 10)
	n_trt	28 (26, 30)	30 (26, 42)	30 (30, 30)
	n_control	46 (36, 55)	61 (46, 87)	27 (27, 27)
	post_p	0.92 (0.91, 0.93)	0.98 (0.93, 1)	0.98 (0.98, 0.98)
	order	2.5 (2.1, 2.9)	2 (1, 3)	1 (1, 1)
TEfus+	count		308		1
	time_stop		15 (9, 29)		12 (12, 12)
	n_trt		43 (26, 105)		25 (25, 25)
	n_control		59 (33, 123)		49 (49, 49)
	post_p		1 (0.95, 1)		0.96 (0.96, 0.96)
	order		1 (1, 2)		1 (1, 1)

Futility:

signature	var	Hormone_therapies	Taxel_therapies	Carboplatin	Niraparib
all	count	18			4
	time_stop	10 (3, 29)			26 (14, 35)
	n_trt	56 (27, 106)			94 (64, 133)
	n_control	104 (35, 384)			286 (153, 422)
	post_p	0.02 (0, 0.23)			0 (0, 0.01)
	order	2 (1, 6)			4.5 (1.3, 7)
TP53- & AR-	count	259	11	205	236
	time_stop	17 (8, 31)	17 (13, 22)	22 (14, 33)	22 (14, 33)
	n_trt	39 (25, 86)	29 (27, 43)	35 (25, 98)	39 (25, 90)
	n_control	74 (33, 145)	68 (61, 107)	102 (61, 166)	104 (56, 162)
	post_p	0.14 (0.04, 0.26)	0.19 (0.09, 0.23)	0.13 (0.03, 0.26)	0.12 (0.03, 0.24)
	order	1 (1, 4)	1 (1, 2)	2 (1, 4)	2 (1, 4)
TP53+	count	70	3	61	75
	time_stop	22 (10, 33)	10 (7, 16)	22 (14, 33)	22 (12, 32)
	n_trt	42 (26, 68)	28 (26, 46)	44 (27, 83)	38 (26, 61)
	n_control	109 (47, 171)	60 (31, 86)	112 (66, 184)	104 (56, 175)
	post_p	0.03 (0, 0.22)	0.19 (0.06, 0.22)	0.02 (0, 0.08)	0.02 (0, 0.12)
	order	2 (1, 5)	1 (1, 1)	2 (1, 5)	2 (1, 5)
DRD+	count	45		48	74
	time_stop	30 (19, 34)		26 (14, 35)	24 (16, 34)
	n_trt	31 (25, 45)		38 (26, 59)	36 (26, 52)
	n_control	86 (52, 110)		84 (42, 113)	74 (44, 106)
	post_p	0.04 (0, 0.17)		0.03 (0, 0.11)	0.02 (0, 0.1)
	order	3 (1.4, 6)		3 (1, 6)	3.5 (1, 6)
TEfus+	count	207		228	215
	time_stop	25 (16, 34)		26 (17, 34)	24 (16, 34)
	n_trt	38 (26, 67)		48 (27, 76)	43 (26, 76)
	n_control	107 (62, 152)		112 (62, 159)	105 (62, 155)
	post_p	0.01 (0, 0.08)		0.01 (0, 0.06)	0.01 (0, 0.07)
	order	3 (1, 5)		3 (1, 5)	3 (1, 5)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5	5
		time	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)	6 (4, 8)
		n	17 (10, 23)	2 (0, 3)	7 (4, 9)	3 (1, 5)	0 (0, 0)	0 (0, 1)	0 (0, 1)	0 (0, 2)	2 (0, 4)	1 (0, 4)	1 (0, 2)	1 (0, 3)	0 (0, 1)	0 (0, 3)	0 (0, 1)	0 (0, 0)
		post_p	0.69 (0.59, 0.87)	0.62 (0.61, 0.68)	0.72 (0.63, 0.87)	0.56 (0.52, 0.7)	NA (NA, NA)	0.61 (0.61, 0.61)	NA (NA, NA)	NA (NA, NA)	0.58 (0.52, 0.63)	0.65 (0.64, 0.67)	0.57 (0.53, 0.6)	0.56 (0.55, 0.62)	0.63 (0.61, 0.64)	0.55 (0.55, 0.55)	0.58 (0.58, 0.58)	NA (NA, NA)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.059 (0.028, 0.091)	0 (0, 0)	0 (0, 0.083)	0 (0, 0.095)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.128 (0.128, 0.128)	0 (0, 0)	0 (0, 0)	0 (0, 0.092)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)
	Taxel_therapies	count	21	21	21	21	21	21	21	21	21	21	21	21	21	21	21	21
		time	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)	6 (5, 15)
		n	9 (5, 16)	3 (1, 8)	6 (2, 12)	9 (5, 13)	0 (0, 2)	0 (0, 2)	0 (0, 2)	0 (0, 2)	3 (0, 8)	3 (1, 5)	3 (0, 6)	2 (0, 3)	0 (0, 3)	0 (0, 1)	0 (0, 2)	0 (0, 2)
		post_p	0.65 (0.54, 0.86)	0.64 (0.52, 0.87)	0.62 (0.54, 0.74)	0.78 (0.61, 0.96)	0.54 (0.5, 0.62)	0.59 (0.52, 0.76)	0.56 (0.51, 0.63)	0.62 (0.55, 0.72)	0.59 (0.51, 0.75)	0.66 (0.51, 0.84)	0.6 (0.5, 0.76)	0.57 (0.53, 0.74)	0.58 (0.51, 0.62)	0.69 (0.55, 0.73)	0.54 (0.52, 0.55)	0.56 (0.52, 0.78)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)	0.17 (0.17, 0.17)	0.41 (0.41, 0.41)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.41 (0.41, 0.41)	0.41 (0.41, 0.41)	0.37 (0.37, 0.37)	0.37 (0.37, 0.37)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.08 (0, 0.121)	0 (0, 0.126)	0.082 (0, 0.142)	0 (0, 0.037)	0 (0, 0.01)	0 (0, 0.01)	0 (0, 0.099)	0 (0, 0.071)	0.05 (0, 0.112)	0 (0, 0.012)	0.048 (0, 0.122)	0 (0, 0.056)	0 (0, 0.118)	0 (0, 0.051)	0 (0, 0.148)	0 (0, 0.015)
	Carboplatin	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)	11 (11, 11)
		n	19 (19, 19)	3 (3, 3)	15 (15, 15)	3 (3, 3)	4 (4, 4)	4 (4, 4)	0 (0, 0)	1 (1, 1)	2 (2, 2)	0 (0, 0)	2 (2, 2)	2 (2, 2)	0 (0, 0)	2 (2, 2)	1 (1, 1)	0 (0, 0)
		post_p	0.78 (0.78, 0.78)	0.68 (0.68, 0.68)	0.65 (0.65, 0.65)	0.69 (0.69, 0.69)	0.5 (0.5, 0.5)	0.5 (0.5, 0.5)	NA (NA, NA)	0.64 (0.64, 0.64)	0.51 (0.51, 0.51)	NA (NA, NA)	0.59 (0.59, 0.59)	0.55 (0.55, 0.55)	NA (NA, NA)	0.71 (0.71, 0.71)	0.56 (0.56, 0.56)	NA (NA, NA)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.079 (0.079, 0.079)	0 (0, 0)	0.079 (0.079, 0.079)	0 (0, 0)	0.067 (0.067, 0.067)	0.053 (0.053, 0.053)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)
	Niraparib	count	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1	1
		time	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)	7 (7, 7)
		n	7 (7, 7)	0 (0, 0)	4 (4, 4)	1 (1, 1)	3 (3, 3)	3 (3, 3)	0 (0, 0)	4 (4, 4)	0 (0, 0)	0 (0, 0)	1 (1, 1)	5 (5, 5)	3 (3, 3)	0 (0, 0)	1 (1, 1)	2 (2, 2)
		post_p	0.62 (0.62, 0.62)	NA (NA, NA)	0.71 (0.71, 0.71)	0.51 (0.51, 0.51)	0.56 (0.56, 0.56)	0.52 (0.52, 0.52)	NA (NA, NA)	0.89 (0.89, 0.89)	NA (NA, NA)	NA (NA, NA)	0.53 (0.53, 0.53)	0.71 (0.71, 0.71)	0.6 (0.6, 0.6)	NA (NA, NA)	0.52 (0.52, 0.52)	NA (NA, NA)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.058 (0.058, 0.058)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.112 (0.112, 0.112)	0.081 (0.081, 0.081)	NA (NA, NA)	0.05 (0.05, 0.05)	NA (NA, NA)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0.105 (0.105, 0.105)	NA (NA, NA)	0 (0, 0)	0 (0, 0)
TP53- & AR-	Hormone_therapies	count	29	29			29	29
		time	10 (6, 14)	10 (6, 14)			10 (6, 14)	10 (6, 14)
		n	25 (20, 38)	4 (1, 5)			1 (0, 4)	1 (0, 3)
		post_p	0.86 (0.74, 0.94)	0.62 (0.52, 0.76)			0.59 (0.52, 0.84)	0.56 (0.51, 0.74)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.073 (0.056, 0.101)	0.017 (0, 0.087)			0 (0, 0.069)	0 (0, 0.097)
	Taxel_therapies	count	115	115			115	115
		time	16 (10, 30)	16 (10, 30)			16 (10, 30)	16 (10, 30)
		n	21 (15, 47)	6 (3, 12)			3 (0, 7)	3 (1, 10)
		post_p	0.8 (0.72, 0.91)	0.8 (0.61, 0.95)			0.59 (0.51, 0.81)	0.7 (0.54, 0.95)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.08 (0.055, 0.103)	0.028 (0, 0.06)			0.077 (0, 0.14)	0.014 (0, 0.071)
	Carboplatin	count	9	9			9	9
		time	13 (9, 19)	13 (9, 19)			13 (9, 19)	13 (9, 19)
		n	19 (15, 35)	2 (0, 4)			6 (2, 9)	4 (1, 12)
		post_p	0.79 (0.75, 0.85)	0.6 (0.53, 0.66)			0.74 (0.53, 0.8)	0.72 (0.52, 0.83)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.074 (0.063, 0.103)	0.038 (0, 0.115)			0.063 (0.026, 0.175)	0.038 (0, 0.101)
	Niraparib	count	9	9			9	9
		time	12 (9, 13)	12 (9, 13)			12 (9, 13)	12 (9, 13)
		n	17 (12, 23)	3 (0, 3)			5 (3, 6)	7 (2, 8)
		post_p	0.76 (0.71, 0.91)	0.58 (0.53, 0.67)			0.72 (0.54, 0.83)	0.72 (0.64, 0.86)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.065 (0.024, 0.1)	0 (0, 0.066)			0.067 (0, 0.076)	0.051 (0, 0.08)
TP53+	Hormone_therapies	count			1	1			1	1			1	1			1	1
		time			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)			8 (8, 8)	8 (8, 8)
		n			23 (23, 23)	2 (2, 2)			0 (0, 0)	0 (0, 0)			0 (0, 0)	1 (1, 1)			0 (0, 0)	0 (0, 0)
		post_p			0.89 (0.89, 0.89)	0.62 (0.62, 0.62)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	NA (NA, NA)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.052 (0.052, 0.052)	0 (0, 0)			NA (NA, NA)	NA (NA, NA)			NA (NA, NA)	0.402 (0.402, 0.402)			NA (NA, NA)	NA (NA, NA)
	Taxel_therapies	count			31	31			31	31			31	31			31	31
		time			10 (8, 21)	10 (8, 21)			10 (8, 21)	10 (8, 21)			10 (8, 21)	10 (8, 21)			10 (8, 21)	10 (8, 21)
		n			9 (5, 18)	12 (9, 18)			1 (0, 5)	1 (0, 3)			4 (1, 9)	5 (2, 10)			1 (0, 3)	1 (0, 4)
		post_p			0.82 (0.71, 0.91)	0.87 (0.74, 0.98)			0.59 (0.51, 0.72)	0.64 (0.57, 0.77)			0.64 (0.53, 0.88)	0.7 (0.58, 0.92)			0.65 (0.53, 0.78)	0.56 (0.51, 0.79)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.048 (0, 0.086)	0.026 (0, 0.048)			0 (0, 0.102)	0 (0, 0.084)			0.068 (0, 0.141)	0.012 (0, 0.073)			0 (0, 0.101)	0 (0, 0.129)
	Carboplatin	count			3	3			3	3			3	3			3	3
		time			12 (11, 21)	12 (11, 21)			12 (11, 21)	12 (11, 21)			12 (11, 21)	12 (11, 21)			12 (11, 21)	12 (11, 21)
		n			14 (11, 14)	5 (2, 10)			1 (0, 3)	2 (0, 3)			4 (2, 4)	0 (0, 2)			3 (1, 5)	3 (2, 4)
		post_p			0.85 (0.75, 0.9)	0.55 (0.51, 0.79)			0.73 (0.66, 0.81)	0.73 (0.69, 0.77)			0.51 (0.51, 0.59)	0.62 (0.62, 0.62)			0.57 (0.53, 0.58)	0.63 (0.62, 0.82)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.065 (0.047, 0.085)	0.036 (0.007, 0.076)			0.061 (0.012, 0.11)	0 (0, 0)			0.081 (0.016, 0.109)	0 (0, 0)			0.06 (0.012, 0.061)	0.067 (0.057, 0.1)
	Niraparib	count			2	2			2	2			2	2			2	2
		time			10 (8, 12)	10 (8, 12)			10 (8, 12)	10 (8, 12)			10 (8, 12)	10 (8, 12)			10 (8, 12)	10 (8, 12)
		n			12 (9, 14)	4 (4, 5)			3 (2, 4)	4 (2, 6)			1 (0, 2)	2 (2, 3)			4 (4, 4)	1 (1, 1)
		post_p			0.9 (0.88, 0.93)	0.66 (0.56, 0.75)			0.65 (0.63, 0.67)	0.75 (0.74, 0.75)			0.61 (0.61, 0.61)	0.56 (0.54, 0.59)			0.7 (0.7, 0.7)	0.62 (0.54, 0.7)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.031 (0.006, 0.056)	0.042 (0.008, 0.076)			0.076 (0.015, 0.137)	0 (0, 0)			0 (0, 0)	0 (0, 0)			0.106 (0.085, 0.126)	0 (0, 0)
DRD+	Hormone_therapies	count					2	2	2	2					2	2	2	2
		time					18 (14, 21)	18 (14, 21)	18 (14, 21)	18 (14, 21)					18 (14, 21)	18 (14, 21)	18 (14, 21)	18 (14, 21)
		n					5 (3, 7)	4 (3, 5)	4 (2, 6)	2 (2, 2)					3 (2, 4)	2 (1, 4)	3 (2, 4)	4 (3, 6)
		post_p					0.65 (0.58, 0.72)	0.57 (0.54, 0.6)	0.66 (0.56, 0.77)	0.51 (0.51, 0.51)					0.59 (0.59, 0.59)	0.52 (0.52, 0.52)	0.8 (0.7, 0.9)	0.63 (0.53, 0.73)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.097 (0.084, 0.111)	0.05 (0.01, 0.09)	0.046 (0.009, 0.083)	0.106 (0.084, 0.128)					0.042 (0.008, 0.076)	0.076 (0.076, 0.076)	0.047 (0.009, 0.084)	0.059 (0.031, 0.087)
	Taxel_therapies	count					20	20	20	20					20	20	20	20
		time					22 (18, 27)	22 (18, 27)	22 (18, 27)	22 (18, 27)					22 (18, 27)	22 (18, 27)	22 (18, 27)	22 (18, 27)
		n					4 (2, 12)	4 (2, 10)	3 (1, 5)	4 (0, 5)					4 (1, 7)	3 (1, 5)	3 (0, 6)	3 (0, 6)
		post_p					0.71 (0.52, 0.83)	0.83 (0.71, 0.95)	0.66 (0.52, 0.79)	0.7 (0.55, 0.91)					0.67 (0.59, 0.8)	0.71 (0.54, 0.88)	0.66 (0.53, 0.76)	0.77 (0.54, 0.91)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.079 (0.026, 0.114)	0.023 (0, 0.055)	0.076 (0, 0.128)	0.028 (0, 0.096)					0.062 (0, 0.111)	0.026 (0, 0.082)	0.081 (0.013, 0.162)	0.035 (0, 0.09)
	Carboplatin	count					1	1	1	1					1	1	1	1
		time					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)					10 (10, 10)	10 (10, 10)	10 (10, 10)	10 (10, 10)
		n					8 (8, 8)	5 (5, 5)	4 (4, 4)	0 (0, 0)					3 (3, 3)	2 (2, 2)	4 (4, 4)	4 (4, 4)
		post_p					0.83 (0.83, 0.83)	0.98 (0.98, 0.98)	0.73 (0.73, 0.73)	NA (NA, NA)					0.53 (0.53, 0.53)	0.57 (0.57, 0.57)	0.58 (0.58, 0.58)	0.63 (0.63, 0.63)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.049 (0.049, 0.049)	0 (0, 0)	0 (0, 0)	NA (NA, NA)					0.149 (0.149, 0.149)	0.089 (0.089, 0.089)	0.056 (0.056, 0.056)	0 (0, 0)
TEfus+	Taxel_therapies	count		308		308		308		308		308		308		308		308
		time		15 (9, 29)		15 (9, 29)		15 (9, 29)		15 (9, 29)		15 (9, 29)		15 (9, 29)		15 (9, 29)		15 (9, 29)
		n		7 (3, 16)		15 (8, 35)		3 (1, 12)		2 (0, 7)		6 (2, 13)		5 (2, 12)		2 (0, 7)		2 (0, 7)
		post_p		0.78 (0.56, 0.97)		0.88 (0.73, 0.99)		0.72 (0.53, 0.92)		0.65 (0.52, 0.86)		0.75 (0.56, 0.93)		0.76 (0.55, 0.93)		0.66 (0.53, 0.86)		0.66 (0.52, 0.89)
		r_prob		0.29 (0.29, 0.29)		0.41 (0.41, 0.41)		0 (0, 0)		0 (0, 0)		0.41 (0.41, 0.41)		0.37 (0.37, 0.37)		0 (0, 0)		0 (0, 0)
		rate		0.029 (0, 0.067)		0.033 (0.013, 0.054)		0 (0, 0.064)		0 (0, 0.081)		0.027 (0, 0.07)		0.03 (0, 0.071)		0 (0, 0.066)		0 (0, 0.071)
	Niraparib	count		1		1		1		1		1		1		1		1
		time		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)		12 (12, 12)
		n		2 (2, 2)		2 (2, 2)		10 (10, 10)		2 (2, 2)		2 (2, 2)		2 (2, 2)		2 (2, 2)		3 (3, 3)
		post_p		0.67 (0.67, 0.67)		0.57 (0.57, 0.57)		0.71 (0.71, 0.71)		0.51 (0.51, 0.51)		0.6 (0.6, 0.6)		0.57 (0.57, 0.57)		0.77 (0.77, 0.77)		0.72 (0.72, 0.72)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0 (0, 0)		0 (0, 0)		0.065 (0.065, 0.065)		0.053 (0.053, 0.053)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	Hormone_therapies	count	18	18	18	18	18	18	18	18	18	18	18	18	18	18	18	18
		time	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)	10 (3, 29)
		n	20 (13, 46)	3 (1, 5)	10 (6, 30)	4 (1, 5)	0 (0, 4)	0 (0, 3)	0 (0, 3)	1 (0, 3)	2 (0, 7)	2 (1, 5)	1 (0, 4)	1 (0, 5)	0 (0, 4)	0 (0, 7)	0 (0, 2)	0 (0, 3)
		post_p	0.27 (0.09, 0.41)	0.35 (0.22, 0.42)	0.33 (0.21, 0.44)	0.32 (0.1, 0.46)	0.39 (0.2, 0.49)	0.29 (0.15, 0.44)	0.3 (0.21, 0.48)	0.4 (0.19, 0.49)	0.32 (0.15, 0.46)	0.32 (0.24, 0.43)	0.32 (0.23, 0.48)	0.33 (0.2, 0.46)	0.38 (0.15, 0.47)	0.36 (0.24, 0.4)	0.32 (0.21, 0.4)	0.37 (0.32, 0.46)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)	0.33 (0.33, 0.33)	0.18 (0.18, 0.18)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.18 (0.18, 0.18)	0.18 (0.18, 0.18)	0.12 (0.12, 0.12)	0.12 (0.12, 0.12)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate	0.135 (0.1, 0.191)	0.155 (0.03, 0.402)	0.126 (0.088, 0.214)	0.18 (0.088, 0.312)	0.197 (0.086, 0.449)	0.195 (0.11, 8.641)	0.184 (0.079, 0.243)	0.128 (0.072, 0.3)	0.266 (0.109, 0.956)	0.139 (0, 0.271)	0.191 (0.101, 1.29)	0.176 (0.009, 0.743)	0.174 (0.059, 0.561)	0.168 (0.063, 0.545)	0.339 (0.255, 1.021)	0.156 (0.057, 1.486)
	Niraparib	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
		time	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)
		n	19 (9, 30)	4 (1, 11)	12 (8, 18)	13 (6, 17)	4 (2, 6)	3 (2, 7)	5 (1, 8)	4 (1, 10)	2 (0, 6)	4 (2, 8)	2 (1, 6)	4 (2, 7)	3 (2, 7)	3 (2, 4)	3 (3, 5)	3 (2, 4)
		post_p	0.41 (0.23, 0.47)	0.31 (0.11, 0.4)	0.25 (0.16, 0.4)	0.4 (0.28, 0.42)	0.35 (0.21, 0.49)	0.31 (0.25, 0.44)	0.43 (0.22, 0.44)	0.43 (0.27, 0.49)	0.42 (0.38, 0.46)	0.42 (0.27, 0.48)	0.31 (0.18, 0.46)	0.24 (0.16, 0.36)	0.19 (0.14, 0.3)	0.17 (0.13, 0.28)	0.39 (0.18, 0.39)	0.37 (0.19, 0.49)
		r_prob	0 (0, 0)	0 (0, 0)	0.08 (0.08, 0.08)	0 (0, 0)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.125 (0.118, 0.181)	0.127 (0.07, 0.155)	0.134 (0.123, 0.16)	0.102 (0.084, 0.186)	0.198 (0.11, 0.829)	0.129 (0.126, 0.135)	0.203 (0.141, 0.273)	0.103 (0.089, 0.381)	0.139 (0.092, 0.699)	0.1 (0.085, 0.147)	0.287 (0.163, 0.595)	0.182 (0.14, 1.748)	0.409 (0.195, 1.03)	0.194 (0.175, 0.201)	0.161 (0.142, 0.254)	0.181 (0.155, 0.391)
TP53- & AR-	Hormone_therapies	count	259	259			259	259
		time	17 (8, 31)	17 (8, 31)			17 (8, 31)	17 (8, 31)
		n	25 (17, 65)	5 (2, 10)			3 (0, 8)	3 (0, 9)
		post_p	0.34 (0.12, 0.47)	0.32 (0.14, 0.46)			0.38 (0.23, 0.48)	0.35 (0.16, 0.48)
		r_prob	0.44 (0.44, 0.44)	0.35 (0.35, 0.35)			0 (0, 0)	0 (0, 0)
		rate	0.125 (0.105, 0.166)	0.137 (0.072, 0.325)			0.164 (0.092, 0.529)	0.148 (0.076, 0.563)
	Taxel_therapies	count	11	11			11	11
		time	17 (13, 22)	17 (13, 22)			17 (13, 22)	17 (13, 22)
		n	23 (13, 35)	5 (2, 9)			4 (0, 5)	2 (1, 4)
		post_p	0.35 (0.24, 0.45)	0.32 (0.27, 0.41)			0.42 (0.24, 0.44)	0.44 (0.32, 0.47)
		r_prob	0.11 (0.11, 0.11)	0.29 (0.29, 0.29)			0 (0, 0)	0 (0, 0)
		rate	0.143 (0.107, 0.152)	0.114 (0.078, 0.312)			0.152 (0.094, 0.31)	0.125 (0.063, 0.521)
	Carboplatin	count	205	205			205	205
		time	22 (14, 33)	22 (14, 33)			22 (14, 33)	22 (14, 33)
		n	17 (8, 65)	4 (2, 13)			6 (2, 16)	6 (3, 15)
		post_p	0.33 (0.11, 0.48)	0.32 (0.13, 0.45)			0.37 (0.17, 0.48)	0.31 (0.12, 0.48)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.131 (0.105, 0.198)	0.145 (0.091, 0.423)			0.145 (0.103, 0.402)	0.13 (0.083, 0.3)
	Niraparib	count	236	236			236	236
		time	22 (14, 33)	22 (14, 33)			22 (14, 33)	22 (14, 33)
		n	22 (9, 58)	4 (1, 12)			6 (2, 14)	6 (2, 13)
		post_p	0.36 (0.13, 0.47)	0.32 (0.14, 0.46)			0.38 (0.16, 0.49)	0.27 (0.1, 0.44)
		r_prob	0 (0, 0)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate	0.128 (0.106, 0.197)	0.141 (0.084, 0.418)			0.159 (0.104, 0.417)	0.148 (0.091, 0.378)
TP53+	Hormone_therapies	count			70	70			70	70			70	70			70	70
		time			22 (10, 33)	22 (10, 33)			22 (10, 33)	22 (10, 33)			22 (10, 33)	22 (10, 33)			22 (10, 33)	22 (10, 33)
		n			14 (6, 35)	8 (3, 14)			2 (0, 6)	2 (1, 8)			3 (1, 7)	3 (1, 10)			2 (0, 5)	2 (1, 6)
		post_p			0.3 (0.1, 0.46)	0.24 (0.07, 0.45)			0.38 (0.18, 0.49)	0.34 (0.17, 0.48)			0.34 (0.15, 0.47)	0.33 (0.18, 0.48)			0.35 (0.26, 0.48)	0.36 (0.18, 0.48)
		r_prob			0.33 (0.33, 0.33)	0.18 (0.18, 0.18)			0 (0, 0)	0 (0, 0)			0.12 (0.12, 0.12)	0.12 (0.12, 0.12)			0 (0, 0)	0 (0, 0)
		rate			0.129 (0.102, 0.242)	0.129 (0.089, 0.304)			0.176 (0.077, 0.6)	0.162 (0.089, 0.556)			0.197 (0.108, 0.892)	0.14 (0.083, 0.658)			0.213 (0.12, 0.666)	0.18 (0.042, 0.751)
	Taxel_therapies	count			3	3			3	3			3	3			3	3
		time			10 (7, 16)	10 (7, 16)			10 (7, 16)	10 (7, 16)			10 (7, 16)	10 (7, 16)			10 (7, 16)	10 (7, 16)
		n			11 (9, 17)	9 (8, 9)			2 (0, 3)	0 (0, 1)			6 (1, 6)	4 (3, 9)			0 (0, 2)	0 (0, 3)
		post_p			0.4 (0.2, 0.44)	0.44 (0.24, 0.48)			0.32 (0.28, 0.36)	0.5 (0.5, 0.5)			0.14 (0.08, 0.19)	0.38 (0.23, 0.43)			0.49 (0.49, 0.49)	0.37 (0.37, 0.37)
		r_prob			0.17 (0.17, 0.17)	0.41 (0.41, 0.41)			0 (0, 0)	0 (0, 0)			0.37 (0.37, 0.37)	0.37 (0.37, 0.37)			0 (0, 0)	0 (0, 0)
		rate			0.128 (0.118, 0.134)	0.085 (0.054, 0.09)			0.178 (0.036, 0.321)	0 (0, 0)			0.184 (0.143, 0.225)	0.082 (0.069, 0.153)			0.27 (0.27, 0.27)	0.129 (0.129, 0.129)
	Carboplatin	count			61	61			61	61			61	61			61	61
		time			22 (14, 33)	22 (14, 33)			22 (14, 33)	22 (14, 33)			22 (14, 33)	22 (14, 33)			22 (14, 33)	22 (14, 33)
		n			12 (3, 35)	8 (4, 23)			3 (1, 9)	4 (1, 7)			3 (1, 8)	4 (1, 9)			3 (1, 8)	3 (1, 8)
		post_p			0.3 (0.14, 0.48)	0.24 (0.08, 0.44)			0.33 (0.21, 0.48)	0.38 (0.18, 0.49)			0.36 (0.22, 0.48)	0.36 (0.18, 0.48)			0.38 (0.22, 0.47)	0.32 (0.16, 0.45)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.141 (0.111, 0.422)	0.126 (0.086, 0.263)			0.211 (0.107, 0.609)	0.152 (0.085, 0.39)			0.174 (0.103, 0.766)	0.14 (0.07, 0.698)			0.18 (0.111, 0.482)	0.176 (0.082, 0.597)
	Niraparib	count			75	75			75	75			75	75			75	75
		time			22 (12, 32)	22 (12, 32)			22 (12, 32)	22 (12, 32)			22 (12, 32)	22 (12, 32)			22 (12, 32)	22 (12, 32)
		n			10 (5, 23)	5 (2, 16)			3 (1, 7)	4 (1, 8)			3 (1, 7)	3 (1, 8)			3 (1, 6)	3 (1, 7)
		post_p			0.34 (0.11, 0.47)	0.32 (0.1, 0.47)			0.37 (0.19, 0.48)	0.3 (0.13, 0.45)			0.35 (0.23, 0.48)	0.35 (0.17, 0.46)			0.34 (0.2, 0.48)	0.34 (0.18, 0.48)
		r_prob			0.08 (0.08, 0.08)	0 (0, 0)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate			0.135 (0.104, 0.244)	0.127 (0.08, 0.459)			0.197 (0.104, 0.479)	0.192 (0.089, 0.436)			0.185 (0.102, 0.915)	0.16 (0.086, 0.958)			0.205 (0.103, 0.982)	0.155 (0.076, 0.414)
DRD+	Hormone_therapies	count					45	45	45	45					45	45	45	45
		time					30 (19, 34)	30 (19, 34)	30 (19, 34)	30 (19, 34)					30 (19, 34)	30 (19, 34)	30 (19, 34)	30 (19, 34)
		n					4 (1, 9)	5 (1, 14)	3 (1, 8)	3 (1, 9)					4 (2, 7)	3 (1, 7)	3 (1, 9)	4 (1, 9)
		post_p					0.34 (0.16, 0.48)	0.28 (0.14, 0.46)	0.34 (0.19, 0.48)	0.32 (0.14, 0.43)					0.4 (0.24, 0.49)	0.37 (0.12, 0.46)	0.36 (0.21, 0.48)	0.35 (0.21, 0.48)
		r_prob					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
		rate					0.168 (0.114, 0.406)	0.143 (0.088, 0.37)	0.201 (0.106, 2.566)	0.165 (0.091, 0.806)					0.169 (0.1, 0.434)	0.159 (0.086, 0.619)	0.179 (0.11, 0.965)	0.139 (0.082, 0.626)
	Carboplatin	count					48	48	48	48					48	48	48	48
		time					26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)					26 (14, 35)	26 (14, 35)	26 (14, 35)	26 (14, 35)
		n					6 (2, 14)	6 (3, 12)	3 (1, 7)	4 (2, 8)					3 (1, 9)	4 (2, 9)	3 (2, 8)	4 (1, 10)
		post_p					0.36 (0.18, 0.49)	0.28 (0.1, 0.44)	0.34 (0.22, 0.47)	0.35 (0.14, 0.47)					0.35 (0.21, 0.48)	0.33 (0.15, 0.47)	0.38 (0.18, 0.48)	0.35 (0.18, 0.46)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.155 (0.098, 0.458)	0.119 (0.088, 0.269)	0.2 (0.115, 0.68)	0.127 (0.072, 0.343)					0.184 (0.109, 0.687)	0.148 (0.091, 0.385)	0.189 (0.099, 0.474)	0.136 (0.085, 0.371)
	Niraparib	count					74	74	74	74					74	74	74	74
		time					24 (16, 34)	24 (16, 34)	24 (16, 34)	24 (16, 34)					24 (16, 34)	24 (16, 34)	24 (16, 34)	24 (16, 34)
		n					6 (2, 12)	7 (3, 13)	3 (1, 8)	3 (1, 8)					3 (1, 8)	4 (1, 7)	3 (1, 7)	3 (1, 7)
		post_p					0.36 (0.16, 0.48)	0.27 (0.13, 0.44)	0.35 (0.21, 0.46)	0.31 (0.15, 0.46)					0.35 (0.21, 0.47)	0.32 (0.16, 0.46)	0.37 (0.17, 0.47)	0.32 (0.14, 0.45)
		r_prob					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)					0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)	0.33 (0.33, 0.33)
		rate					0.152 (0.107, 0.317)	0.131 (0.087, 0.39)	0.171 (0.097, 0.546)	0.157 (0.086, 0.492)					0.171 (0.113, 0.415)	0.159 (0.088, 0.393)	0.188 (0.106, 0.835)	0.165 (0.087, 0.543)
TEfus+	Hormone_therapies	count		207		207		207		207		207		207		207		207
		time		25 (16, 34)		25 (16, 34)		25 (16, 34)		25 (16, 34)		25 (16, 34)		25 (16, 34)		25 (16, 34)		25 (16, 34)
		n		5 (2, 11)		8 (4, 22)		4 (1, 12)		3 (1, 7)		4 (2, 11)		4 (1, 10)		3 (1, 7)		3 (1, 8)
		post_p		0.28 (0.13, 0.45)		0.21 (0.06, 0.44)		0.32 (0.14, 0.48)		0.34 (0.17, 0.47)		0.32 (0.15, 0.47)		0.31 (0.14, 0.47)		0.34 (0.19, 0.48)		0.36 (0.19, 0.46)
		r_prob		0.35 (0.35, 0.35)		0.18 (0.18, 0.18)		0 (0, 0)		0 (0, 0)		0.18 (0.18, 0.18)		0.12 (0.12, 0.12)		0 (0, 0)		0 (0, 0)
		rate		0.145 (0.082, 0.313)		0.125 (0.085, 0.267)		0.138 (0.084, 0.452)		0.155 (0.084, 0.509)		0.138 (0.085, 0.446)		0.141 (0.087, 0.551)		0.167 (0.086, 0.652)		0.147 (0.085, 0.491)
	Carboplatin	count		228		228		228		228		228		228		228		228
		time		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)		26 (17, 34)
		n		5 (2, 13)		8 (3, 24)		7 (3, 16)		4 (2, 11)		4 (1, 10)		4 (1, 9)		4 (2, 9)		4 (2, 9)
		post_p		0.32 (0.14, 0.46)		0.24 (0.08, 0.48)		0.3 (0.11, 0.48)		0.35 (0.14, 0.47)		0.31 (0.15, 0.46)		0.3 (0.15, 0.44)		0.33 (0.15, 0.47)		0.32 (0.16, 0.47)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.137 (0.08, 0.388)		0.119 (0.079, 0.291)		0.122 (0.083, 0.268)		0.139 (0.087, 0.418)		0.144 (0.085, 0.514)		0.153 (0.085, 0.498)		0.148 (0.086, 0.45)		0.142 (0.084, 0.396)
	Niraparib	count		215		215		215		215		215		215		215		215
		time		24 (16, 34)		24 (16, 34)		24 (16, 34)		24 (16, 34)		24 (16, 34)		24 (16, 34)		24 (16, 34)		24 (16, 34)
		n		4 (1, 14)		7 (3, 22)		6 (2, 15)		4 (2, 10)		4 (1, 10)		4 (1, 9)		4 (1, 8)		4 (2, 8)
		post_p		0.3 (0.15, 0.44)		0.24 (0.08, 0.46)		0.3 (0.1, 0.47)		0.33 (0.16, 0.46)		0.33 (0.17, 0.47)		0.33 (0.16, 0.45)		0.33 (0.17, 0.46)		0.36 (0.2, 0.48)
		r_prob		0 (0, 0)		0 (0, 0)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
		rate		0.142 (0.088, 0.568)		0.13 (0.082, 0.314)		0.133 (0.085, 0.349)		0.143 (0.087, 0.394)		0.138 (0.083, 0.393)		0.143 (0.083, 0.495)		0.158 (0.084, 0.506)		0.142 (0.081, 0.293)