Setting description

Taxel_therapies more effective in the TEfus+ biomarker signature

Simulations setting

PFS distributions


Treatment effects

By subgroup:

subtype var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
—+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
–+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
–++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-+– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
-++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
-+++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+— param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+–+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+-+- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
+-++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
++– param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++-+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1
+++- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1 af = 1, hr = 1
++++ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1


By signature:

signature var Other Hormone_therapies Taxel_therapies Carboplatin Niraparib
all param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1, hr = 1 af = 1, hr = 1
TP53- & AR- param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1, hr = 1 af = 1, hr = 1
TP53+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1, hr = 1 af = 1, hr = 1
DRD+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.075, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 13.1, median = 9.4 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 1.49, hr = 0.66 af = 1, hr = 1 af = 1, hr = 1
TEfus+ param scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.037, shape = 1.05 scale = 0.112, shape = 1.05 scale = 0.112, shape = 1.05
summary mean = 8.8, median = 6.3 mean = 8.8, median = 6.3 mean = 26.6, median = 19.1 mean = 8.8, median = 6.3 mean = 8.8, median = 6.3
effect af = 1, hr = 1 af = 1, hr = 1 af = 3.03, hr = 0.31 af = 1, hr = 1 af = 1, hr = 1

Errors and power


graduation (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 5 21 1 1
TP53- & AR- 29 115 9 9
TP53+ 1 31 3 2
DRD+ 2 20 1 0
TEfus+ 0 308 0 1
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.010 0.042 0.002 0.002
TP53- & AR- 0.058 0.230 0.018 0.018
TP53+ 0.002 0.062 0.006 0.004
DRD+ 0.004 0.040 0.002 0.000
TEfus+ 0.000 0.616 0.000 0.002
futility (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 18 0 0 4
TP53- & AR- 259 11 205 236
TP53+ 70 3 61 75
DRD+ 45 0 48 74
TEfus+ 207 0 228 215
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.036 0.000 0.000 0.008
TP53- & AR- 0.518 0.022 0.410 0.472
TP53+ 0.140 0.006 0.122 0.150
DRD+ 0.090 0.000 0.096 0.148
TEfus+ 0.414 0.000 0.456 0.430
max sample size (counts and proportions):
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0 0 0 0
TP53- & AR- 18 11 19 11
TP53+ 7 26 8 8
DRD+ 0 0 0 0
TEfus+ 2 21 2 2
Hormone_therapies Taxel_therapies Carboplatin Niraparib
all 0.000 0.000 0.000 0.000
TP53- & AR- 0.036 0.022 0.038 0.022
TP53+ 0.014 0.052 0.016 0.016
DRD+ 0.000 0.000 0.000 0.000
TEfus+ 0.004 0.042 0.004 0.004


Errors & power

The overall error was 0.22.
The corresponding errors separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.072             0.112             0.028             0.026 

The overall power was 0.616.
The corresponding power separate for the different treatments were:

Hormone_therapies   Taxel_therapies       Carboplatin         Niraparib 
            0.000             0.616             0.000             0.000 

Median results at the end of the trial

By signature:
signature var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
all graduation 0 5 21 1 1
futility 0 18 0 0 4
max_n 0 0 0 0 0
n 432 (394, 467) 170 (108, 250) 187 (104, 269) 180 (119, 253) 173 (113, 239)
n_unique 399 (364, 430) 157 (99, 231) 171 (94, 251) 168 (108, 237) 160 (102, 221)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36)
time_stop NA (NA, NA) 7 (3, 29) 6 (5, 15) 11 (11, 11) 18 (9, 35)
post_p NA (NA, NA) 0.06 (0, 0.37) 1 (0.91, 1) 0.07 (0, 0.39) 0.05 (0, 0.38)
rate 0.096 (0.089, 0.103) 0.113 (0.102, 0.128) 0.067 (0.057, 0.083) 0.112 (0.101, 0.126) 0.113 (0.101, 0.128)
TP53- & AR- graduation 0 29 115 9 9
futility 0 259 11 205 236
max_n 0 18 11 19 11
n 177 (153, 201) 61 (26, 130) 60 (26, 119) 69 (27, 132) 64 (27, 117)
n_unique 165 (141, 188) 57 (25, 123) 54 (24, 112) 64 (24, 123) 58 (24, 110)
time_trial 36 (36, 36) 28 (9, 36) 36 (14, 36) 36 (16, 36) 36 (15, 36)
time_stop NA (NA, NA) 15 (7, 30) 16 (10, 28) 22 (13, 33) 22 (13, 33)
post_p NA (NA, NA) 0.25 (0.04, 0.73) 0.94 (0.48, 1) 0.26 (0.03, 0.72) 0.22 (0.03, 0.69)
rate 0.101 (0.091, 0.114) 0.115 (0.096, 0.142) 0.078 (0.058, 0.103) 0.113 (0.096, 0.144) 0.117 (0.098, 0.147)
TP53+ graduation 0 1 31 3 2
futility 0 70 3 61 75
max_n 0 7 26 8 8
n 194 (172, 216) 79 (36, 116) 90 (41, 137) 81 (45, 118) 79 (40, 116)
n_unique 178 (156, 199) 72 (34, 108) 83 (38, 128) 74 (41, 108) 73 (36, 108)
time_trial 36 (36, 36) 36 (28, 36) 36 (36, 36) 36 (31, 36) 36 (24, 36)
time_stop NA (NA, NA) 22 (10, 33) 10 (7, 20) 22 (13, 33) 21 (12, 32)
post_p NA (NA, NA) 0.1 (0.01, 0.47) 1 (0.84, 1) 0.11 (0.01, 0.46) 0.1 (0.01, 0.48)
rate 0.093 (0.083, 0.104) 0.114 (0.098, 0.138) 0.062 (0.049, 0.079) 0.114 (0.097, 0.136) 0.115 (0.097, 0.138)
DRD+ graduation 0 2 20 1 0
futility 0 45 0 48 74
max_n 0 0 0 0 0
n 117 (100, 133) 42 (25, 66) 42 (20, 74) 59 (38, 84) 55 (35, 82)
n_unique 107 (90, 122) 38 (22, 61) 38 (18, 68) 54 (35, 79) 51 (31, 76)
time_trial 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (36, 36) 36 (28, 36)
time_stop NA (NA, NA) 28 (19, 34) 22 (18, 27) 25 (14, 35) 24 (16, 34)
post_p NA (NA, NA) 0.18 (0.02, 0.62) 0.94 (0.54, 1) 0.13 (0.02, 0.56) 0.12 (0.01, 0.49)
rate 0.091 (0.078, 0.105) 0.113 (0.089, 0.147) 0.064 (0.048, 0.093) 0.113 (0.095, 0.138) 0.117 (0.095, 0.144)
TEfus+ graduation 0 0 308 0 1
futility 0 207 0 228 215
max_n 0 2 21 2 2
n 163 (143, 183) 51 (27, 94) 72 (26, 141) 59 (32, 97) 54 (29, 101)
n_unique 150 (130, 169) 46 (24, 87) 65 (25, 128) 54 (29, 88) 49 (27, 92)
time_trial 36 (36, 36) 36 (19, 36) 24 (10, 36) 36 (20, 36) 36 (19, 36)
time_stop NA (NA, NA) 25 (16, 34) 15 (9, 29) 26 (17, 34) 24 (16, 34)
post_p NA (NA, NA) 0.02 (0, 0.18) 1 (1, 1) 0.01 (0, 0.15) 0.02 (0, 0.15)
rate 0.074 (0.065, 0.086) 0.115 (0.095, 0.145) 0.036 (0.029, 0.044) 0.114 (0.095, 0.14) 0.115 (0.095, 0.143)


By subgroup combinations:
subtype var Control Hormone_therapies Taxel_therapies Carboplatin Niraparib
—- graduation 0 299 144 215 247
futility 0 0 0 0 0
max_n 0 18 11 19 11
n 113 (93, 134) 39 (17, 99) 31 (10, 82) 38 (9, 90) 32 (10, 84)
n_unique 105 (85, 126) 37 (17, 94) 29 (9, 77) 36 (8, 86) 30 (9, 78)
post_p NA (NA, NA) 0.47 (0.11, 0.89) 0.43 (0.09, 0.88) 0.47 (0.09, 0.89) 0.42 (0.09, 0.89)
rate 0.112 (0.099, 0.129) 0.116 (0.094, 0.153) 0.116 (0.091, 0.18) 0.116 (0.093, 0.184) 0.119 (0.093, 0.18)
—+ graduation 0 368 364 333 350
futility 0 0 0 0 0
max_n 0 19 31 20 12
n 21 (14, 28) 6 (2, 16) 8 (3, 22) 6 (2, 17) 5 (2, 17)
n_unique 19 (12, 26) 5 (2, 14) 7 (2, 21) 5 (1, 16) 5 (1, 15)
post_p NA (NA, NA) 0.27 (0.09, 0.55) 0.92 (0.58, 1) 0.26 (0.11, 0.55) 0.28 (0.1, 0.57)
rate 0.074 (0.05, 0.111) 0.127 (0.076, 0.297) 0.036 (0.02, 0.07) 0.127 (0.078, 0.356) 0.134 (0.08, 0.381)
–+- graduation 0 85 54 65 78
futility 0 0 0 0 0
max_n 0 7 26 8 8
n 63 (50, 77) 25 (8, 59) 22 (7, 53) 24 (6, 52) 24 (7, 53)
n_unique 58 (44, 72) 24 (8, 55) 21 (6, 49) 22 (6, 50) 23 (6, 49)
post_p NA (NA, NA) 0.44 (0.09, 0.89) 0.48 (0.13, 0.88) 0.44 (0.11, 0.87) 0.46 (0.12, 0.86)
rate 0.114 (0.094, 0.14) 0.117 (0.093, 0.196) 0.118 (0.087, 0.193) 0.122 (0.091, 0.235) 0.121 (0.089, 0.212)
–++ graduation 0 247 330 261 251
futility 0 0 0 0 0
max_n 0 9 43 9 8
n 47 (36, 57) 10 (4, 31) 22 (9, 50) 11 (3, 32) 10 (3, 29)
n_unique 43 (33, 54) 9 (3, 30) 21 (8, 46) 10 (3, 30) 9 (3, 27)
post_p NA (NA, NA) 0.18 (0.04, 0.44) 0.99 (0.84, 1) 0.21 (0.05, 0.5) 0.19 (0.06, 0.49)
rate 0.075 (0.058, 0.096) 0.123 (0.084, 0.241) 0.036 (0.025, 0.052) 0.118 (0.078, 0.25) 0.123 (0.079, 0.258)
-+– graduation 0 320 158 235 269
futility 0 0 0 0 0
max_n 0 18 11 19 11
n 21 (14, 28) 5 (1, 16) 6 (1, 18) 10 (3, 22) 9 (3, 22)
n_unique 19 (13, 26) 4 (1, 15) 5 (1, 16) 9 (3, 21) 8 (2, 20)
post_p NA (NA, NA) 0.48 (0.21, 0.83) 0.48 (0.16, 0.84) 0.45 (0.17, 0.84) 0.43 (0.17, 0.85)
rate 0.113 (0.084, 0.16) 0.125 (0.071, 0.36) 0.122 (0.07, 0.332) 0.125 (0.081, 0.289) 0.128 (0.079, 0.307)
-+-+ graduation 0 381 366 339 359
futility 0 0 0 0 0
max_n 0 19 31 20 12
n 21 (14, 29) 5 (1, 16) 5 (1, 20) 8 (3, 19) 7 (2, 19)
n_unique 19 (12, 26) 4 (1, 15) 5 (1, 19) 8 (3, 18) 7 (2, 17)
post_p NA (NA, NA) 0.3 (0.11, 0.6) 0.88 (0.51, 0.99) 0.26 (0.09, 0.59) 0.25 (0.1, 0.53)
rate 0.076 (0.053, 0.111) 0.131 (0.073, 0.431) 0.036 (0.013, 0.082) 0.119 (0.076, 0.255) 0.125 (0.082, 0.336)
-++- graduation 0 121 71 98 123
futility 0 0 0 0 0
max_n 0 7 26 8 7
n 12 (7, 17) 4 (1, 10) 4 (1, 10) 6 (2, 13) 5 (2, 12)
n_unique 11 (6, 16) 4 (1, 9) 3 (1, 9) 5 (2, 12) 5 (2, 12)
post_p NA (NA, NA) 0.46 (0.23, 0.83) 0.45 (0.23, 0.79) 0.46 (0.21, 0.82) 0.44 (0.21, 0.8)
rate 0.114 (0.073, 0.17) 0.125 (0.064, 0.386) 0.132 (0.068, 0.396) 0.125 (0.071, 0.343) 0.135 (0.073, 0.358)
-+++ graduation 0 263 332 272 264
futility 0 0 0 0 0
max_n 0 9 43 9 8
n 13 (8, 18) 4 (1, 11) 3 (0, 11) 5 (2, 12) 5 (2, 13)
n_unique 11 (7, 16) 4 (1, 10) 3 (0, 10) 5 (2, 11) 4 (2, 12)
post_p NA (NA, NA) 0.35 (0.17, 0.61) 0.78 (0.41, 0.96) 0.32 (0.14, 0.62) 0.31 (0.13, 0.63)
rate 0.074 (0.045, 0.123) 0.128 (0.07, 0.396) 0.042 (0, 0.126) 0.132 (0.071, 0.326) 0.131 (0.071, 0.345)
+— graduation 0 23 21 1 5
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 20 (14, 27) 9 (2, 18) 10 (3, 20) 8 (3, 17) 8 (2, 17)
n_unique 18 (12, 25) 8 (2, 16) 10 (3, 19) 7 (2, 16) 7 (2, 15)
post_p NA (NA, NA) 0.43 (0.18, 0.84) 0.46 (0.16, 0.84) 0.47 (0.19, 0.86) 0.48 (0.19, 0.82)
rate 0.115 (0.082, 0.157) 0.128 (0.078, 0.342) 0.124 (0.081, 0.27) 0.121 (0.074, 0.308) 0.12 (0.073, 0.323)
+–+ graduation 0 221 324 229 218
futility 0 0 0 0 0
max_n 0 2 21 2 2
n 17 (12, 24) 5 (2, 14) 8 (3, 18) 5 (2, 13) 5 (2, 13)
n_unique 16 (11, 22) 4 (2, 13) 7 (2, 17) 4 (1, 12) 4 (1, 12)
post_p NA (NA, NA) 0.29 (0.14, 0.55) 0.88 (0.58, 0.99) 0.3 (0.12, 0.58) 0.31 (0.14, 0.62)
rate 0.075 (0.046, 0.11) 0.128 (0.078, 0.374) 0.038 (0.02, 0.072) 0.131 (0.071, 0.359) 0.128 (0.069, 0.365)
+-+- graduation 0 85 54 65 78
futility 0 0 0 0 0
max_n 0 7 26 8 8
n 16 (11, 22) 6 (2, 15) 8 (3, 17) 6 (2, 15) 6 (2, 15)
n_unique 15 (10, 20) 6 (1, 14) 7 (2, 15) 6 (2, 14) 6 (2, 14)
post_p NA (NA, NA) 0.45 (0.19, 0.83) 0.48 (0.17, 0.84) 0.45 (0.19, 0.81) 0.45 (0.2, 0.82)
rate 0.114 (0.078, 0.164) 0.128 (0.073, 0.391) 0.124 (0.075, 0.294) 0.13 (0.077, 0.553) 0.129 (0.073, 0.432)
+-++ graduation 0 247 330 261 251
futility 0 0 0 0 0
max_n 0 9 43 9 8
n 17 (12, 24) 5 (2, 14) 7 (2, 19) 5 (2, 13) 5 (2, 13)
n_unique 16 (10, 22) 5 (1, 12) 7 (2, 17) 5 (1, 12) 4 (1, 12)
post_p NA (NA, NA) 0.27 (0.13, 0.58) 0.89 (0.56, 0.99) 0.3 (0.12, 0.55) 0.3 (0.12, 0.59)
rate 0.076 (0.049, 0.113) 0.133 (0.075, 0.358) 0.037 (0.016, 0.074) 0.133 (0.074, 0.382) 0.133 (0.065, 0.375)
++– graduation 0 67 41 50 77
futility 0 0 0 0 0
max_n 0 0 0 0 0
n 11 (7, 17) 5 (1, 11) 4 (1, 10) 6 (2, 13) 5 (2, 12)
n_unique 11 (6, 16) 4 (1, 10) 4 (1, 9) 6 (2, 12) 5 (2, 11)
post_p NA (NA, NA) 0.48 (0.23, 0.82) 0.44 (0.22, 0.8) 0.46 (0.2, 0.84) 0.43 (0.21, 0.82)
rate 0.114 (0.071, 0.175) 0.125 (0.058, 0.41) 0.13 (0.066, 0.53) 0.128 (0.071, 0.36) 0.133 (0.074, 0.374)
++-+ graduation 0 238 327 243 246
futility 0 0 0 0 0
max_n 0 2 21 2 2
n 12 (8, 18) 4 (1, 11) 3 (0, 11) 5 (2, 12) 5 (2, 12)
n_unique 11 (7, 16) 3 (1, 9) 3 (0, 10) 5 (1, 11) 4 (2, 11)
post_p NA (NA, NA) 0.34 (0.16, 0.64) 0.79 (0.44, 0.96) 0.32 (0.14, 0.63) 0.31 (0.13, 0.61)
rate 0.074 (0.043, 0.125) 0.132 (0.067, 0.539) 0.04 (0.007, 0.105) 0.129 (0.072, 0.375) 0.136 (0.074, 0.359)
+++- graduation 0 121 71 98 123
futility 0 0 0 0 0
max_n 0 7 26 8 7
n 12 (7, 17) 4 (1, 11) 4 (1, 10) 6 (2, 13) 5 (2, 12)
n_unique 11 (6, 16) 4 (1, 10) 4 (1, 9) 5 (2, 12) 5 (2, 12)
post_p NA (NA, NA) 0.44 (0.22, 0.8) 0.45 (0.2, 0.79) 0.48 (0.22, 0.83) 0.43 (0.2, 0.8)
rate 0.114 (0.07, 0.184) 0.135 (0.069, 0.454) 0.133 (0.067, 0.418) 0.122 (0.075, 0.355) 0.133 (0.075, 0.462)
++++ graduation 0 263 332 272 264
futility 0 0 0 0 0
max_n 0 9 43 9 8
n 12 (8, 18) 4 (1, 11) 3 (0, 11) 5 (2, 12) 5 (2, 12)
n_unique 11 (7, 17) 4 (1, 10) 3 (0, 10) 5 (2, 11) 4 (2, 11)
post_p NA (NA, NA) 0.35 (0.17, 0.68) 0.81 (0.47, 0.96) 0.32 (0.14, 0.63) 0.33 (0.15, 0.7)
rate 0.079 (0.047, 0.131) 0.13 (0.063, 0.393) 0.036 (0, 0.111) 0.13 (0.071, 0.36) 0.126 (0.069, 0.317)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 5 21 1 1
time_stop 6 (4, 8) 6 (5, 15) 11 (11, 11) 7 (7, 7)
n_trt 31 (28, 50) 38 (29, 75) 58 (58, 58) 34 (34, 34)
n_control 64 (50, 95) 71 (54, 158) 114 (114, 114) 64 (64, 64)
post_p 0.92 (0.9, 0.98) 0.98 (0.92, 1) 0.98 (0.98, 0.98) 0.94 (0.94, 0.94)
order 1 (1, 2.6) 1 (1, 2) 1 (1, 1) 1 (1, 1)
TP53- & AR- count 29 115 9 9
time_stop 10 (6, 14) 16 (10, 30) 13 (9, 19) 12 (9, 13)
n_trt 30 (25, 50) 34 (25, 68) 28 (25, 53) 28 (27, 36)
n_control 36 (25, 60) 68 (40, 136) 55 (47, 85) 49 (40, 61)
post_p 0.9 (0.86, 0.98) 0.96 (0.88, 1) 0.9 (0.89, 0.95) 0.93 (0.87, 0.97)
order 1 (1, 1) 1 (1, 2) 1 (1, 2.2) 1 (1, 2)
TP53+ count 1 31 3 2
time_stop 8 (8, 8) 10 (8, 21) 12 (11, 21) 10 (8, 12)
n_trt 26 (26, 26) 34 (26, 64) 31 (26, 37) 32 (30, 33)
n_control 33 (33, 33) 52 (31, 122) 62 (48, 108) 46 (36, 56)
post_p 0.88 (0.88, 0.88) 0.99 (0.94, 1) 0.93 (0.89, 0.97) 0.97 (0.95, 0.99)
order 1 (1, 1) 1 (1, 2) 2 (1.2, 2) 1.5 (1.1, 1.9)
DRD+ count 2 20 1
time_stop 18 (14, 21) 22 (18, 27) 10 (10, 10)
n_trt 28 (26, 30) 30 (26, 42) 30 (30, 30)
n_control 46 (36, 55) 61 (46, 87) 27 (27, 27)
post_p 0.92 (0.91, 0.93) 0.98 (0.93, 1) 0.98 (0.98, 0.98)
order 2.5 (2.1, 2.9) 2 (1, 3) 1 (1, 1)
TEfus+ count 308 1
time_stop 15 (9, 29) 12 (12, 12)
n_trt 43 (26, 105) 25 (25, 25)
n_control 59 (33, 123) 49 (49, 49)
post_p 1 (0.95, 1) 0.96 (0.96, 0.96)
order 1 (1, 2) 1 (1, 1)
Futility:
signature var Hormone_therapies Taxel_therapies Carboplatin Niraparib
all count 18 4
time_stop 10 (3, 29) 26 (14, 35)
n_trt 56 (27, 106) 94 (64, 133)
n_control 104 (35, 384) 286 (153, 422)
post_p 0.02 (0, 0.23) 0 (0, 0.01)
order 2 (1, 6) 4.5 (1.3, 7)
TP53- & AR- count 259 11 205 236
time_stop 17 (8, 31) 17 (13, 22) 22 (14, 33) 22 (14, 33)
n_trt 39 (25, 86) 29 (27, 43) 35 (25, 98) 39 (25, 90)
n_control 74 (33, 145) 68 (61, 107) 102 (61, 166) 104 (56, 162)
post_p 0.14 (0.04, 0.26) 0.19 (0.09, 0.23) 0.13 (0.03, 0.26) 0.12 (0.03, 0.24)
order 1 (1, 4) 1 (1, 2) 2 (1, 4) 2 (1, 4)
TP53+ count 70 3 61 75
time_stop 22 (10, 33) 10 (7, 16) 22 (14, 33) 22 (12, 32)
n_trt 42 (26, 68) 28 (26, 46) 44 (27, 83) 38 (26, 61)
n_control 109 (47, 171) 60 (31, 86) 112 (66, 184) 104 (56, 175)
post_p 0.03 (0, 0.22) 0.19 (0.06, 0.22) 0.02 (0, 0.08) 0.02 (0, 0.12)
order 2 (1, 5) 1 (1, 1) 2 (1, 5) 2 (1, 5)
DRD+ count 45 48 74
time_stop 30 (19, 34) 26 (14, 35) 24 (16, 34)
n_trt 31 (25, 45) 38 (26, 59) 36 (26, 52)
n_control 86 (52, 110) 84 (42, 113) 74 (44, 106)
post_p 0.04 (0, 0.17) 0.03 (0, 0.11) 0.02 (0, 0.1)
order 3 (1.4, 6) 3 (1, 6) 3.5 (1, 6)
TEfus+ count 207 228 215
time_stop 25 (16, 34) 26 (17, 34) 24 (16, 34)
n_trt 38 (26, 67) 48 (27, 76) 43 (26, 76)
n_control 107 (62, 152) 112 (62, 159) 105 (62, 155)
post_p 0.01 (0, 0.08) 0.01 (0, 0.06) 0.01 (0, 0.07)
order 3 (1, 5) 3 (1, 5) 3 (1, 5)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5 5
time 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8) 6 (4, 8)
n 17 (10, 23) 2 (0, 3) 7 (4, 9) 3 (1, 5) 0 (0, 0) 0 (0, 1) 0 (0, 1) 0 (0, 2) 2 (0, 4) 1 (0, 4) 1 (0, 2) 1 (0, 3) 0 (0, 1) 0 (0, 3) 0 (0, 1) 0 (0, 0)
post_p 0.69 (0.59, 0.87) 0.62 (0.61, 0.68) 0.72 (0.63, 0.87) 0.56 (0.52, 0.7) NA (NA, NA) 0.61 (0.61, 0.61) NA (NA, NA) NA (NA, NA) 0.58 (0.52, 0.63) 0.65 (0.64, 0.67) 0.57 (0.53, 0.6) 0.56 (0.55, 0.62) 0.63 (0.61, 0.64) 0.55 (0.55, 0.55) 0.58 (0.58, 0.58) NA (NA, NA)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.059 (0.028, 0.091) 0 (0, 0) 0 (0, 0.083) 0 (0, 0.095) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.128 (0.128, 0.128) 0 (0, 0) 0 (0, 0) 0 (0, 0.092) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA)
Taxel_therapies count 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21 21
time 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15) 6 (5, 15)
n 9 (5, 16) 3 (1, 8) 6 (2, 12) 9 (5, 13) 0 (0, 2) 0 (0, 2) 0 (0, 2) 0 (0, 2) 3 (0, 8) 3 (1, 5) 3 (0, 6) 2 (0, 3) 0 (0, 3) 0 (0, 1) 0 (0, 2) 0 (0, 2)
post_p 0.65 (0.54, 0.86) 0.64 (0.52, 0.87) 0.62 (0.54, 0.74) 0.78 (0.61, 0.96) 0.54 (0.5, 0.62) 0.59 (0.52, 0.76) 0.56 (0.51, 0.63) 0.62 (0.55, 0.72) 0.59 (0.51, 0.75) 0.66 (0.51, 0.84) 0.6 (0.5, 0.76) 0.57 (0.53, 0.74) 0.58 (0.51, 0.62) 0.69 (0.55, 0.73) 0.54 (0.52, 0.55) 0.56 (0.52, 0.78)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.08 (0, 0.121) 0 (0, 0.126) 0.082 (0, 0.142) 0 (0, 0.037) 0 (0, 0.01) 0 (0, 0.01) 0 (0, 0.099) 0 (0, 0.071) 0.05 (0, 0.112) 0 (0, 0.012) 0.048 (0, 0.122) 0 (0, 0.056) 0 (0, 0.118) 0 (0, 0.051) 0 (0, 0.148) 0 (0, 0.015)
Carboplatin count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11) 11 (11, 11)
n 19 (19, 19) 3 (3, 3) 15 (15, 15) 3 (3, 3) 4 (4, 4) 4 (4, 4) 0 (0, 0) 1 (1, 1) 2 (2, 2) 0 (0, 0) 2 (2, 2) 2 (2, 2) 0 (0, 0) 2 (2, 2) 1 (1, 1) 0 (0, 0)
post_p 0.78 (0.78, 0.78) 0.68 (0.68, 0.68) 0.65 (0.65, 0.65) 0.69 (0.69, 0.69) 0.5 (0.5, 0.5) 0.5 (0.5, 0.5) NA (NA, NA) 0.64 (0.64, 0.64) 0.51 (0.51, 0.51) NA (NA, NA) 0.59 (0.59, 0.59) 0.55 (0.55, 0.55) NA (NA, NA) 0.71 (0.71, 0.71) 0.56 (0.56, 0.56) NA (NA, NA)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.079 (0.079, 0.079) 0 (0, 0) 0.079 (0.079, 0.079) 0 (0, 0) 0.067 (0.067, 0.067) 0.053 (0.053, 0.053) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA)
Niraparib count 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1 1
time 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7) 7 (7, 7)
n 7 (7, 7) 0 (0, 0) 4 (4, 4) 1 (1, 1) 3 (3, 3) 3 (3, 3) 0 (0, 0) 4 (4, 4) 0 (0, 0) 0 (0, 0) 1 (1, 1) 5 (5, 5) 3 (3, 3) 0 (0, 0) 1 (1, 1) 2 (2, 2)
post_p 0.62 (0.62, 0.62) NA (NA, NA) 0.71 (0.71, 0.71) 0.51 (0.51, 0.51) 0.56 (0.56, 0.56) 0.52 (0.52, 0.52) NA (NA, NA) 0.89 (0.89, 0.89) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) 0.71 (0.71, 0.71) 0.6 (0.6, 0.6) NA (NA, NA) 0.52 (0.52, 0.52) NA (NA, NA)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.058 (0.058, 0.058) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.112 (0.112, 0.112) 0.081 (0.081, 0.081) NA (NA, NA) 0.05 (0.05, 0.05) NA (NA, NA) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0.105 (0.105, 0.105) NA (NA, NA) 0 (0, 0) 0 (0, 0)
TP53- & AR- Hormone_therapies count 29 29 29 29
time 10 (6, 14) 10 (6, 14) 10 (6, 14) 10 (6, 14)
n 25 (20, 38) 4 (1, 5) 1 (0, 4) 1 (0, 3)
post_p 0.86 (0.74, 0.94) 0.62 (0.52, 0.76) 0.59 (0.52, 0.84) 0.56 (0.51, 0.74)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.073 (0.056, 0.101) 0.017 (0, 0.087) 0 (0, 0.069) 0 (0, 0.097)
Taxel_therapies count 115 115 115 115
time 16 (10, 30) 16 (10, 30) 16 (10, 30) 16 (10, 30)
n 21 (15, 47) 6 (3, 12) 3 (0, 7) 3 (1, 10)
post_p 0.8 (0.72, 0.91) 0.8 (0.61, 0.95) 0.59 (0.51, 0.81) 0.7 (0.54, 0.95)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.08 (0.055, 0.103) 0.028 (0, 0.06) 0.077 (0, 0.14) 0.014 (0, 0.071)
Carboplatin count 9 9 9 9
time 13 (9, 19) 13 (9, 19) 13 (9, 19) 13 (9, 19)
n 19 (15, 35) 2 (0, 4) 6 (2, 9) 4 (1, 12)
post_p 0.79 (0.75, 0.85) 0.6 (0.53, 0.66) 0.74 (0.53, 0.8) 0.72 (0.52, 0.83)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.074 (0.063, 0.103) 0.038 (0, 0.115) 0.063 (0.026, 0.175) 0.038 (0, 0.101)
Niraparib count 9 9 9 9
time 12 (9, 13) 12 (9, 13) 12 (9, 13) 12 (9, 13)
n 17 (12, 23) 3 (0, 3) 5 (3, 6) 7 (2, 8)
post_p 0.76 (0.71, 0.91) 0.58 (0.53, 0.67) 0.72 (0.54, 0.83) 0.72 (0.64, 0.86)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.065 (0.024, 0.1) 0 (0, 0.066) 0.067 (0, 0.076) 0.051 (0, 0.08)
TP53+ Hormone_therapies count 1 1 1 1 1 1 1 1
time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
n 23 (23, 23) 2 (2, 2) 0 (0, 0) 0 (0, 0) 0 (0, 0) 1 (1, 1) 0 (0, 0) 0 (0, 0)
post_p 0.89 (0.89, 0.89) 0.62 (0.62, 0.62) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.052 (0.052, 0.052) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.402 (0.402, 0.402) NA (NA, NA) NA (NA, NA)
Taxel_therapies count 31 31 31 31 31 31 31 31
time 10 (8, 21) 10 (8, 21) 10 (8, 21) 10 (8, 21) 10 (8, 21) 10 (8, 21) 10 (8, 21) 10 (8, 21)
n 9 (5, 18) 12 (9, 18) 1 (0, 5) 1 (0, 3) 4 (1, 9) 5 (2, 10) 1 (0, 3) 1 (0, 4)
post_p 0.82 (0.71, 0.91) 0.87 (0.74, 0.98) 0.59 (0.51, 0.72) 0.64 (0.57, 0.77) 0.64 (0.53, 0.88) 0.7 (0.58, 0.92) 0.65 (0.53, 0.78) 0.56 (0.51, 0.79)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.048 (0, 0.086) 0.026 (0, 0.048) 0 (0, 0.102) 0 (0, 0.084) 0.068 (0, 0.141) 0.012 (0, 0.073) 0 (0, 0.101) 0 (0, 0.129)
Carboplatin count 3 3 3 3 3 3 3 3
time 12 (11, 21) 12 (11, 21) 12 (11, 21) 12 (11, 21) 12 (11, 21) 12 (11, 21) 12 (11, 21) 12 (11, 21)
n 14 (11, 14) 5 (2, 10) 1 (0, 3) 2 (0, 3) 4 (2, 4) 0 (0, 2) 3 (1, 5) 3 (2, 4)
post_p 0.85 (0.75, 0.9) 0.55 (0.51, 0.79) 0.73 (0.66, 0.81) 0.73 (0.69, 0.77) 0.51 (0.51, 0.59) 0.62 (0.62, 0.62) 0.57 (0.53, 0.58) 0.63 (0.62, 0.82)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.065 (0.047, 0.085) 0.036 (0.007, 0.076) 0.061 (0.012, 0.11) 0 (0, 0) 0.081 (0.016, 0.109) 0 (0, 0) 0.06 (0.012, 0.061) 0.067 (0.057, 0.1)
Niraparib count 2 2 2 2 2 2 2 2
time 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12) 10 (8, 12)
n 12 (9, 14) 4 (4, 5) 3 (2, 4) 4 (2, 6) 1 (0, 2) 2 (2, 3) 4 (4, 4) 1 (1, 1)
post_p 0.9 (0.88, 0.93) 0.66 (0.56, 0.75) 0.65 (0.63, 0.67) 0.75 (0.74, 0.75) 0.61 (0.61, 0.61) 0.56 (0.54, 0.59) 0.7 (0.7, 0.7) 0.62 (0.54, 0.7)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.031 (0.006, 0.056) 0.042 (0.008, 0.076) 0.076 (0.015, 0.137) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.106 (0.085, 0.126) 0 (0, 0)
DRD+ Hormone_therapies count 2 2 2 2 2 2 2 2
time 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21) 18 (14, 21)
n 5 (3, 7) 4 (3, 5) 4 (2, 6) 2 (2, 2) 3 (2, 4) 2 (1, 4) 3 (2, 4) 4 (3, 6)
post_p 0.65 (0.58, 0.72) 0.57 (0.54, 0.6) 0.66 (0.56, 0.77) 0.51 (0.51, 0.51) 0.59 (0.59, 0.59) 0.52 (0.52, 0.52) 0.8 (0.7, 0.9) 0.63 (0.53, 0.73)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.097 (0.084, 0.111) 0.05 (0.01, 0.09) 0.046 (0.009, 0.083) 0.106 (0.084, 0.128) 0.042 (0.008, 0.076) 0.076 (0.076, 0.076) 0.047 (0.009, 0.084) 0.059 (0.031, 0.087)
Taxel_therapies count 20 20 20 20 20 20 20 20
time 22 (18, 27) 22 (18, 27) 22 (18, 27) 22 (18, 27) 22 (18, 27) 22 (18, 27) 22 (18, 27) 22 (18, 27)
n 4 (2, 12) 4 (2, 10) 3 (1, 5) 4 (0, 5) 4 (1, 7) 3 (1, 5) 3 (0, 6) 3 (0, 6)
post_p 0.71 (0.52, 0.83) 0.83 (0.71, 0.95) 0.66 (0.52, 0.79) 0.7 (0.55, 0.91) 0.67 (0.59, 0.8) 0.71 (0.54, 0.88) 0.66 (0.53, 0.76) 0.77 (0.54, 0.91)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.079 (0.026, 0.114) 0.023 (0, 0.055) 0.076 (0, 0.128) 0.028 (0, 0.096) 0.062 (0, 0.111) 0.026 (0, 0.082) 0.081 (0.013, 0.162) 0.035 (0, 0.09)
Carboplatin count 1 1 1 1 1 1 1 1
time 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10) 10 (10, 10)
n 8 (8, 8) 5 (5, 5) 4 (4, 4) 0 (0, 0) 3 (3, 3) 2 (2, 2) 4 (4, 4) 4 (4, 4)
post_p 0.83 (0.83, 0.83) 0.98 (0.98, 0.98) 0.73 (0.73, 0.73) NA (NA, NA) 0.53 (0.53, 0.53) 0.57 (0.57, 0.57) 0.58 (0.58, 0.58) 0.63 (0.63, 0.63)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.049 (0.049, 0.049) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0.149 (0.149, 0.149) 0.089 (0.089, 0.089) 0.056 (0.056, 0.056) 0 (0, 0)
TEfus+ Taxel_therapies count 308 308 308 308 308 308 308 308
time 15 (9, 29) 15 (9, 29) 15 (9, 29) 15 (9, 29) 15 (9, 29) 15 (9, 29) 15 (9, 29) 15 (9, 29)
n 7 (3, 16) 15 (8, 35) 3 (1, 12) 2 (0, 7) 6 (2, 13) 5 (2, 12) 2 (0, 7) 2 (0, 7)
post_p 0.78 (0.56, 0.97) 0.88 (0.73, 0.99) 0.72 (0.53, 0.92) 0.65 (0.52, 0.86) 0.75 (0.56, 0.93) 0.76 (0.55, 0.93) 0.66 (0.53, 0.86) 0.66 (0.52, 0.89)
r_prob 0.29 (0.29, 0.29) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.41 (0.41, 0.41) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.029 (0, 0.067) 0.033 (0.013, 0.054) 0 (0, 0.064) 0 (0, 0.081) 0.027 (0, 0.07) 0.03 (0, 0.071) 0 (0, 0.066) 0 (0, 0.071)
Niraparib count 1 1 1 1 1 1 1 1
time 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12) 12 (12, 12)
n 2 (2, 2) 2 (2, 2) 10 (10, 10) 2 (2, 2) 2 (2, 2) 2 (2, 2) 2 (2, 2) 3 (3, 3)
post_p 0.67 (0.67, 0.67) 0.57 (0.57, 0.57) 0.71 (0.71, 0.71) 0.51 (0.51, 0.51) 0.6 (0.6, 0.6) 0.57 (0.57, 0.57) 0.77 (0.77, 0.77) 0.72 (0.72, 0.72)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0 (0, 0) 0 (0, 0) 0.065 (0.065, 0.065) 0.053 (0.053, 0.053) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all Hormone_therapies count 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18 18
time 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29) 10 (3, 29)
n 20 (13, 46) 3 (1, 5) 10 (6, 30) 4 (1, 5) 0 (0, 4) 0 (0, 3) 0 (0, 3) 1 (0, 3) 2 (0, 7) 2 (1, 5) 1 (0, 4) 1 (0, 5) 0 (0, 4) 0 (0, 7) 0 (0, 2) 0 (0, 3)
post_p 0.27 (0.09, 0.41) 0.35 (0.22, 0.42) 0.33 (0.21, 0.44) 0.32 (0.1, 0.46) 0.39 (0.2, 0.49) 0.29 (0.15, 0.44) 0.3 (0.21, 0.48) 0.4 (0.19, 0.49) 0.32 (0.15, 0.46) 0.32 (0.24, 0.43) 0.32 (0.23, 0.48) 0.33 (0.2, 0.46) 0.38 (0.15, 0.47) 0.36 (0.24, 0.4) 0.32 (0.21, 0.4) 0.37 (0.32, 0.46)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.135 (0.1, 0.191) 0.155 (0.03, 0.402) 0.126 (0.088, 0.214) 0.18 (0.088, 0.312) 0.197 (0.086, 0.449) 0.195 (0.11, 8.641) 0.184 (0.079, 0.243) 0.128 (0.072, 0.3) 0.266 (0.109, 0.956) 0.139 (0, 0.271) 0.191 (0.101, 1.29) 0.176 (0.009, 0.743) 0.174 (0.059, 0.561) 0.168 (0.063, 0.545) 0.339 (0.255, 1.021) 0.156 (0.057, 1.486)
Niraparib count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
time 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35)
n 19 (9, 30) 4 (1, 11) 12 (8, 18) 13 (6, 17) 4 (2, 6) 3 (2, 7) 5 (1, 8) 4 (1, 10) 2 (0, 6) 4 (2, 8) 2 (1, 6) 4 (2, 7) 3 (2, 7) 3 (2, 4) 3 (3, 5) 3 (2, 4)
post_p 0.41 (0.23, 0.47) 0.31 (0.11, 0.4) 0.25 (0.16, 0.4) 0.4 (0.28, 0.42) 0.35 (0.21, 0.49) 0.31 (0.25, 0.44) 0.43 (0.22, 0.44) 0.43 (0.27, 0.49) 0.42 (0.38, 0.46) 0.42 (0.27, 0.48) 0.31 (0.18, 0.46) 0.24 (0.16, 0.36) 0.19 (0.14, 0.3) 0.17 (0.13, 0.28) 0.39 (0.18, 0.39) 0.37 (0.19, 0.49)
r_prob 0 (0, 0) 0 (0, 0) 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.125 (0.118, 0.181) 0.127 (0.07, 0.155) 0.134 (0.123, 0.16) 0.102 (0.084, 0.186) 0.198 (0.11, 0.829) 0.129 (0.126, 0.135) 0.203 (0.141, 0.273) 0.103 (0.089, 0.381) 0.139 (0.092, 0.699) 0.1 (0.085, 0.147) 0.287 (0.163, 0.595) 0.182 (0.14, 1.748) 0.409 (0.195, 1.03) 0.194 (0.175, 0.201) 0.161 (0.142, 0.254) 0.181 (0.155, 0.391)
TP53- & AR- Hormone_therapies count 259 259 259 259
time 17 (8, 31) 17 (8, 31) 17 (8, 31) 17 (8, 31)
n 25 (17, 65) 5 (2, 10) 3 (0, 8) 3 (0, 9)
post_p 0.34 (0.12, 0.47) 0.32 (0.14, 0.46) 0.38 (0.23, 0.48) 0.35 (0.16, 0.48)
r_prob 0.44 (0.44, 0.44) 0.35 (0.35, 0.35) 0 (0, 0) 0 (0, 0)
rate 0.125 (0.105, 0.166) 0.137 (0.072, 0.325) 0.164 (0.092, 0.529) 0.148 (0.076, 0.563)
Taxel_therapies count 11 11 11 11
time 17 (13, 22) 17 (13, 22) 17 (13, 22) 17 (13, 22)
n 23 (13, 35) 5 (2, 9) 4 (0, 5) 2 (1, 4)
post_p 0.35 (0.24, 0.45) 0.32 (0.27, 0.41) 0.42 (0.24, 0.44) 0.44 (0.32, 0.47)
r_prob 0.11 (0.11, 0.11) 0.29 (0.29, 0.29) 0 (0, 0) 0 (0, 0)
rate 0.143 (0.107, 0.152) 0.114 (0.078, 0.312) 0.152 (0.094, 0.31) 0.125 (0.063, 0.521)
Carboplatin count 205 205 205 205
time 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33)
n 17 (8, 65) 4 (2, 13) 6 (2, 16) 6 (3, 15)
post_p 0.33 (0.11, 0.48) 0.32 (0.13, 0.45) 0.37 (0.17, 0.48) 0.31 (0.12, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.131 (0.105, 0.198) 0.145 (0.091, 0.423) 0.145 (0.103, 0.402) 0.13 (0.083, 0.3)
Niraparib count 236 236 236 236
time 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33)
n 22 (9, 58) 4 (1, 12) 6 (2, 14) 6 (2, 13)
post_p 0.36 (0.13, 0.47) 0.32 (0.14, 0.46) 0.38 (0.16, 0.49) 0.27 (0.1, 0.44)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.128 (0.106, 0.197) 0.141 (0.084, 0.418) 0.159 (0.104, 0.417) 0.148 (0.091, 0.378)
TP53+ Hormone_therapies count 70 70 70 70 70 70 70 70
time 22 (10, 33) 22 (10, 33) 22 (10, 33) 22 (10, 33) 22 (10, 33) 22 (10, 33) 22 (10, 33) 22 (10, 33)
n 14 (6, 35) 8 (3, 14) 2 (0, 6) 2 (1, 8) 3 (1, 7) 3 (1, 10) 2 (0, 5) 2 (1, 6)
post_p 0.3 (0.1, 0.46) 0.24 (0.07, 0.45) 0.38 (0.18, 0.49) 0.34 (0.17, 0.48) 0.34 (0.15, 0.47) 0.33 (0.18, 0.48) 0.35 (0.26, 0.48) 0.36 (0.18, 0.48)
r_prob 0.33 (0.33, 0.33) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.12 (0.12, 0.12) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.129 (0.102, 0.242) 0.129 (0.089, 0.304) 0.176 (0.077, 0.6) 0.162 (0.089, 0.556) 0.197 (0.108, 0.892) 0.14 (0.083, 0.658) 0.213 (0.12, 0.666) 0.18 (0.042, 0.751)
Taxel_therapies count 3 3 3 3 3 3 3 3
time 10 (7, 16) 10 (7, 16) 10 (7, 16) 10 (7, 16) 10 (7, 16) 10 (7, 16) 10 (7, 16) 10 (7, 16)
n 11 (9, 17) 9 (8, 9) 2 (0, 3) 0 (0, 1) 6 (1, 6) 4 (3, 9) 0 (0, 2) 0 (0, 3)
post_p 0.4 (0.2, 0.44) 0.44 (0.24, 0.48) 0.32 (0.28, 0.36) 0.5 (0.5, 0.5) 0.14 (0.08, 0.19) 0.38 (0.23, 0.43) 0.49 (0.49, 0.49) 0.37 (0.37, 0.37)
r_prob 0.17 (0.17, 0.17) 0.41 (0.41, 0.41) 0 (0, 0) 0 (0, 0) 0.37 (0.37, 0.37) 0.37 (0.37, 0.37) 0 (0, 0) 0 (0, 0)
rate 0.128 (0.118, 0.134) 0.085 (0.054, 0.09) 0.178 (0.036, 0.321) 0 (0, 0) 0.184 (0.143, 0.225) 0.082 (0.069, 0.153) 0.27 (0.27, 0.27) 0.129 (0.129, 0.129)
Carboplatin count 61 61 61 61 61 61 61 61
time 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33) 22 (14, 33)
n 12 (3, 35) 8 (4, 23) 3 (1, 9) 4 (1, 7) 3 (1, 8) 4 (1, 9) 3 (1, 8) 3 (1, 8)
post_p 0.3 (0.14, 0.48) 0.24 (0.08, 0.44) 0.33 (0.21, 0.48) 0.38 (0.18, 0.49) 0.36 (0.22, 0.48) 0.36 (0.18, 0.48) 0.38 (0.22, 0.47) 0.32 (0.16, 0.45)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.141 (0.111, 0.422) 0.126 (0.086, 0.263) 0.211 (0.107, 0.609) 0.152 (0.085, 0.39) 0.174 (0.103, 0.766) 0.14 (0.07, 0.698) 0.18 (0.111, 0.482) 0.176 (0.082, 0.597)
Niraparib count 75 75 75 75 75 75 75 75
time 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32) 22 (12, 32)
n 10 (5, 23) 5 (2, 16) 3 (1, 7) 4 (1, 8) 3 (1, 7) 3 (1, 8) 3 (1, 6) 3 (1, 7)
post_p 0.34 (0.11, 0.47) 0.32 (0.1, 0.47) 0.37 (0.19, 0.48) 0.3 (0.13, 0.45) 0.35 (0.23, 0.48) 0.35 (0.17, 0.46) 0.34 (0.2, 0.48) 0.34 (0.18, 0.48)
r_prob 0.08 (0.08, 0.08) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.135 (0.104, 0.244) 0.127 (0.08, 0.459) 0.197 (0.104, 0.479) 0.192 (0.089, 0.436) 0.185 (0.102, 0.915) 0.16 (0.086, 0.958) 0.205 (0.103, 0.982) 0.155 (0.076, 0.414)
DRD+ Hormone_therapies count 45 45 45 45 45 45 45 45
time 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34) 30 (19, 34)
n 4 (1, 9) 5 (1, 14) 3 (1, 8) 3 (1, 9) 4 (2, 7) 3 (1, 7) 3 (1, 9) 4 (1, 9)
post_p 0.34 (0.16, 0.48) 0.28 (0.14, 0.46) 0.34 (0.19, 0.48) 0.32 (0.14, 0.43) 0.4 (0.24, 0.49) 0.37 (0.12, 0.46) 0.36 (0.21, 0.48) 0.35 (0.21, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
rate 0.168 (0.114, 0.406) 0.143 (0.088, 0.37) 0.201 (0.106, 2.566) 0.165 (0.091, 0.806) 0.169 (0.1, 0.434) 0.159 (0.086, 0.619) 0.179 (0.11, 0.965) 0.139 (0.082, 0.626)
Carboplatin count 48 48 48 48 48 48 48 48
time 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35) 26 (14, 35)
n 6 (2, 14) 6 (3, 12) 3 (1, 7) 4 (2, 8) 3 (1, 9) 4 (2, 9) 3 (2, 8) 4 (1, 10)
post_p 0.36 (0.18, 0.49) 0.28 (0.1, 0.44) 0.34 (0.22, 0.47) 0.35 (0.14, 0.47) 0.35 (0.21, 0.48) 0.33 (0.15, 0.47) 0.38 (0.18, 0.48) 0.35 (0.18, 0.46)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.155 (0.098, 0.458) 0.119 (0.088, 0.269) 0.2 (0.115, 0.68) 0.127 (0.072, 0.343) 0.184 (0.109, 0.687) 0.148 (0.091, 0.385) 0.189 (0.099, 0.474) 0.136 (0.085, 0.371)
Niraparib count 74 74 74 74 74 74 74 74
time 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34)
n 6 (2, 12) 7 (3, 13) 3 (1, 8) 3 (1, 8) 3 (1, 8) 4 (1, 7) 3 (1, 7) 3 (1, 7)
post_p 0.36 (0.16, 0.48) 0.27 (0.13, 0.44) 0.35 (0.21, 0.46) 0.31 (0.15, 0.46) 0.35 (0.21, 0.47) 0.32 (0.16, 0.46) 0.37 (0.17, 0.47) 0.32 (0.14, 0.45)
r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.152 (0.107, 0.317) 0.131 (0.087, 0.39) 0.171 (0.097, 0.546) 0.157 (0.086, 0.492) 0.171 (0.113, 0.415) 0.159 (0.088, 0.393) 0.188 (0.106, 0.835) 0.165 (0.087, 0.543)
TEfus+ Hormone_therapies count 207 207 207 207 207 207 207 207
time 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34) 25 (16, 34)
n 5 (2, 11) 8 (4, 22) 4 (1, 12) 3 (1, 7) 4 (2, 11) 4 (1, 10) 3 (1, 7) 3 (1, 8)
post_p 0.28 (0.13, 0.45) 0.21 (0.06, 0.44) 0.32 (0.14, 0.48) 0.34 (0.17, 0.47) 0.32 (0.15, 0.47) 0.31 (0.14, 0.47) 0.34 (0.19, 0.48) 0.36 (0.19, 0.46)
r_prob 0.35 (0.35, 0.35) 0.18 (0.18, 0.18) 0 (0, 0) 0 (0, 0) 0.18 (0.18, 0.18) 0.12 (0.12, 0.12) 0 (0, 0) 0 (0, 0)
rate 0.145 (0.082, 0.313) 0.125 (0.085, 0.267) 0.138 (0.084, 0.452) 0.155 (0.084, 0.509) 0.138 (0.085, 0.446) 0.141 (0.087, 0.551) 0.167 (0.086, 0.652) 0.147 (0.085, 0.491)
Carboplatin count 228 228 228 228 228 228 228 228
time 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34) 26 (17, 34)
n 5 (2, 13) 8 (3, 24) 7 (3, 16) 4 (2, 11) 4 (1, 10) 4 (1, 9) 4 (2, 9) 4 (2, 9)
post_p 0.32 (0.14, 0.46) 0.24 (0.08, 0.48) 0.3 (0.11, 0.48) 0.35 (0.14, 0.47) 0.31 (0.15, 0.46) 0.3 (0.15, 0.44) 0.33 (0.15, 0.47) 0.32 (0.16, 0.47)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.137 (0.08, 0.388) 0.119 (0.079, 0.291) 0.122 (0.083, 0.268) 0.139 (0.087, 0.418) 0.144 (0.085, 0.514) 0.153 (0.085, 0.498) 0.148 (0.086, 0.45) 0.142 (0.084, 0.396)
Niraparib count 215 215 215 215 215 215 215 215
time 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34) 24 (16, 34)
n 4 (1, 14) 7 (3, 22) 6 (2, 15) 4 (2, 10) 4 (1, 10) 4 (1, 9) 4 (1, 8) 4 (2, 8)
post_p 0.3 (0.15, 0.44) 0.24 (0.08, 0.46) 0.3 (0.1, 0.47) 0.33 (0.16, 0.46) 0.33 (0.17, 0.47) 0.33 (0.16, 0.45) 0.33 (0.17, 0.46) 0.36 (0.2, 0.48)
r_prob 0 (0, 0) 0 (0, 0) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
rate 0.142 (0.088, 0.568) 0.13 (0.082, 0.314) 0.133 (0.085, 0.349) 0.143 (0.087, 0.394) 0.138 (0.083, 0.393) 0.143 (0.083, 0.495) 0.158 (0.084, 0.506) 0.142 (0.081, 0.293)